正常小鼠免疫功能的昼夜节律性  

INVESTIGATION OF CIRCADIAN IMMUNE RHYTHMS IN MICE

作　　者：杨迎暴[1] 李经才[1] 徐峰[1] 罗景慧[1] 

机构地区：[1]沈阳药科大学药学系,中山医科大学

出　　处：《沈阳药科大学学报》1996年第2期134-138,共5页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金

摘　　要：本文用雌性小鼠研究免疫成分的昼夜节律性。动物自实验前一周置于标准的明暗周期交迭的环境中饲养，自由摄食饮水．在昼夜０４：００，０８：００，１２：００，１６：００，２０：００，２４：００时分别取样测定。结果表明，小鼠血液白细胞（ＷＢＣ）数、淋巴细胞百分率（Ｌｙｍ％），Ｌ－淋巴细胞百分率（Ｔ－Ｌｙｍ％）、碳粒廓清能力以及血清溶血素水平等各项指标均呈现明显的昼夜节律特征，按平均余弦法拟合可得其峰值位相时间分别为０４：０８，０７：５８，０７：５７，２１：１９，０２：５９时。The circadian rhythm of functions was investigated in female mice;Kunming mice had been housed in a standardized light-dark cycle with food and water ad libitum for one week before experiment began.Samples were taken and detennined respectively at six different time points(04:00,08:00,12:00,16:00,20:00 and 24: 00h) in one day-night cycle.The result showed that white blood cell(WBC) count,lymphocyte percentage(Lym% %) and T-lymphocyte percentage(T-Lym%) in peripheral blood, clearance action of charcoal particles and serum hemolysin concentration(HC50 Value) exhibited a significant circadian rhythmicity.

关 键 词：免疫功能 昼夜节律 

分 类 号：R392.1[医药卫生—免疫学]