沐舒坦对老年患者术后呼吸系统并发症的预防作用  

Preventive effect of ambroxol on postoperative respiratory complications in elderly patients undergoing upper abdominal surgery

作　　者：罗文杰[1] 薛庆生[2] 

机构地区：[1]上海市普陀区人民医院麻醉科,200060 [2]上海瑞金医院麻醉科

出　　处：《临床麻醉学杂志》2005年第9期603-604,共2页Journal of Clinical Anesthesiology

摘　　要：目的观察术中使用沐舒坦针剂对于接受上腹部手术老年患者术后呼吸系统并发症的预防作用.方法选择全身麻醉下择期接受上腹部手术的老年患者40例(年龄≥60岁,ASA Ⅰ～Ⅱ级),随机分为两组.沐舒坦组在气管插管后、手术前缓慢静注沐舒坦针剂150 mg;对照组静注相同容量的生理盐水.观察术后两组患者的咳嗽程度、咳痰容易程度、咳痰量、痰液性质,术后24 h脉搏血氧饱和度和肺部情况.结果与对照组比较,沐舒坦组患者咳嗽程度较轻,痰易咳出,痰量少,而且痰液稀薄(P＜0.01).术后24 h脉搏血氧饱和度值较高(P＜0.05).结论沐舒坦对全身麻醉上腹部手术的老年患者术后呼吸系统并发症可能具有一定预防作用.Objective To observe the preventive effect of ambroxol on postoperative respiratory complications in elderly patients. Methods Forty elderly patients（age≥60 years,ASA Ⅰ- Ⅱ ）under- going upper abdominal surgery under general anesthesia were randomly allocated into ambrosol group （n=20）and control group（n=20）. In ambrosoxol group, 150 mg of ambroxol was administered intravenously during anesthesia of induction, and the same volume of normal saline was given in control group. The degrees of cough, easy extend of expectoration,amount of sputum, sputum properties after operation were recorded. SpO2 at 24 h after surgery and the atelectasis were also observed. Results There were significant differences in the severity of cough,ability of expectoration amout of sputum, sputum properties（P〈0.01）between two groups. SpO2 of 24 h after surgery was higher in ambroxol group than that in control group. Conclusion Ambroxol is effective in the prevention of postoperative respiratory complications in surgical elderly patients.

关 键 词：沐舒坦 老年 呼吸系统并发症 呼吸系统并发症 沐舒坦针剂 老年患者 观察术后 预防作用 脉搏血氧饱和度 上腹部手术 全身麻醉 缓慢静注 

分 类 号：R619[医药卫生—外科学]