胸腺肽α1结肠释放片在人体内γ-闪烁扫描示踪研究  

Gamma-scintigraphic evaluation of colon-targeted thymosin α1 tablets

作　　者：张洁[1] 张纯[1] 高申 孔令山[3] 

机构地区：[1]第二军医大学长征医院药学部,上海200003 [2]药学院药剂学教研室,上海200433 [3]长海医院核医学科,上海200433

出　　处：《第二军医大学学报》2005年第9期1026-1028,共3页Academic Journal of Second Military Medical University

基　　金：上海市科技发展攻关基金(2004011-h)

摘　　要：目的:考察胸腺肽α1(Tα1)结肠释放片的体内过程。方法:以99m锝为标记物制备Tα1结肠释放片,经6名男性健康志愿者口服后,利用γ-闪烁扫描示踪技术对Tα1结肠释放片在人体内的胃肠道转运过程和释药部位进行跟踪监测。结果:5名肠蠕动正常的志愿者服药6.5 h后,均可观察到药片已到达结肠部位,而1名肠蠕动亢进的志愿者服药4.5 h后即可观察到药片已到达结肠部位,所有志愿者随时间延长可观察到释药所致的结肠显影。结论:Tα1结肠释放片在人体胃肠道内具有结肠定位释药特性。Objective：To investigate the in vivo behavior of colon targeted thymosin αl （Tαl） tablets. Methods： Colontargeted Tαl tablets were labelled with ^99mTc and were given to 6 healthy male volunteers orally. Gamma-scintigraphy was used to monitor the gastrointestinal transit and release site of the labelled drug. Results： The labelled drug became detectable in the colon 6.5h after administration in 5 volunteers with normal intestinal peristalsis and 4.5 h after administration in 1 with sthenic intestinal peristalsis. The images caused by drug release became notable in the colon with the prolongation of releasing time. Conclusion： Tαl tablets is colon-targeted during drug delivery in human gastrointestinal tract.

关 键 词：胸腺肽Α1 结肠释放片 γ-闪烁扫描示踪 胃肠道转运 

分 类 号：R817[医药卫生—影像医学与核医学]