川崎病患儿血清内皮素1和丙二醛含量的变化及其临床意义  

Changes of endothelin-1 and malondialdehyde in Kawasaki disease and their clinical significance

作　　者：赵建美[1] 徐美玉[1] 蒋晓天[1] 

机构地区：[1]南通大学附属医院儿科,南通226001

出　　处：《第二军医大学学报》2005年第9期1040-1042,共3页Academic Journal of Second Military Medical University

基　　金：南通市社会发展科技计划基金(S40049)

摘　　要：目的:探讨川崎病(Kawasaki disease,KD)患儿血清内皮素1、丙二醛含量的变化及其与冠状动脉病变之间的关系。方法:KD组患儿42例(男25、女17),平均(3.25±0.75)岁;对照组健康儿童30例(男19、女11),平均(3.58±0.55)岁。对两组儿童均采用放免法测定血清内皮素1,采用改良的硫代巴比妥酸法测定血清丙二醛,使用彩色多普勒超声诊断仪测量其左、右冠状动脉内径及主动脉内径。其中KD组患儿再分为冠脉扩张组和冠脉无扩张组并作比较。结果:KD患儿血清内皮素1、丙二醛含量均明显高于对照组[(76.63±18.36)vs(41.55±16.68)pg/ml,(3.18±0.60)vs(1.52±0.24)μmol/L;P<0.01],患儿组中冠脉扩张组该两指标显著高于无扩张组,且血清内皮素1水平与冠脉扩张程度呈正相关(r=0.42,P<0.01)。结论:血清内皮素1、丙二醛可能参与了KD的病理发病机制,内皮素1可作为预测KD并发冠状动脉炎尤其是冠状动脉扩张的生化指标之一。Objective：To study the changes of endothelin-1（ET-1） and malondialdehyde （MDA） in Kawasaki disease （KD） and to probe the relationship between the changes of ET-1, MDA and coronary artery pathological changes. Methods： KD group included 42 patients （male 25, female 17）, with a mean age of （3.25±0.75） years old; control group included 30 normal children （male 19, female 11）, with a mean age of （3.58±0.55） years old. Serum contents of ET-1 and MDA were measured by radioimmunology and modified thiabarbituricaid（TBA） method in 2 groups, and the inner diameters of coronary artery and aorta were measured by color echocardiography. KD group was subdivided into dilated-coronary artery group and undilated group for comparison. Results： Serum contents of ET-1 and MDA in KD group were apparently higher than those in control group （[76.63±18.36] vs [41.55±16.68] pg/ml and [3.18±0.60] vs [1.52±0.24]μmol/L,respeetively;P〈0.O1）. Serum contents of ET-1 and MDA in patients with dilated coronary artery were higher than in those without dilatation, and ET-1 level was positively correlated with the dilatation extents of coronary artery （r=0.42,P〈0.01）. Conclusion： ET-1 and MDA may take part in the pathogenesis of KD, and ET-1 may be taken as a biochemical marker for predicting the inflammation of coronary artery, especially for the dilatation of coronary artery.

关 键 词：川崎病 内皮素1 丙二醛 冠状动脉疾病 

分 类 号：R725.4[医药卫生—儿科]