替硝唑经BALB/c裸小鼠和SD大鼠透皮吸收及贮库效应的比较研究  

Comparative Study on Percutaneous Absorption and Deposit Effect for Tinidaz in BALB/c Nude Mouse and SD Rat

作　　者：李志东[1] 王晖[1] 欧阳轶强[1] 练有文[1] 陈丽[1] 

机构地区：[1]广东医学院实验动物中心,湛江524023

出　　处：《实验动物科学与管理》2005年第3期10-12,共3页Laboratory Animal Science & Administration

摘　　要：目的以替硝唑为模型药物,比较其经BALB/c裸小鼠和SD大鼠透皮吸收及贮库效应的差异。方法在离体透皮吸收实验装置上,测定不同时间替硝唑经两种皮肤的透过量,并测定各自的贮库效应。结果透皮吸收和贮库效应的研究表明,BALB/c裸小鼠对替硝唑的透皮速率比SD大鼠显著增加(P<0.01)。结论BALB/c裸小鼠比SD大鼠更适合用于体外透皮吸收试验。Objective Tinidazole had been taken as model drug to compare the diffrence of percutaneous absorption and deposit effect between BALB/c nude mice and SD rats. Methods Percutaneous absorption experiment was performed with a osmosis device in vitro, then detect the osmosis dose and deposit effect in different time. Results The study on percutaneous absorption and deposit effect showed BALB/c nude mice could increase the penetration rate of Tinidzole than SD rats （ P 〈 0.01 ）. Conclusion percutaneous absorption than SD rats BALB/c nude mice is more suitable for experiment of extrinsic

关 键 词：替硝唑 氮酮 BALB/C裸小鼠 SD大鼠 透皮吸收 贮库效应 

分 类 号：Q95-33[生物学—动物学]