中药枸骨叶脂溶性化学成分的研究  

Liposoluble components from leaves of llex cornuta

作　　者：吴弢[1] 程志红[2] 刘和平[1] 李颜[1] 侴桂新[1] 王峥涛[1] 

机构地区：[1]上海中医药大学中药所 [2]中国科学院上海有机化学研究所上海质谱中心,上海200032

出　　处：《中国药学杂志》2005年第19期1460-1462,共3页Chinese Pharmaceutical Journal

基　　金：上海市教委科研项目青年教师项目(02CQ20)

摘　　要：目的研究中药枸骨叶(Ilexcornuta)的脂溶性化学成分,为其抗动脉粥样硬化活性寻找可能的先导化合物。方法利用硅胶和SephadexIH-20等柱色谱进行分离,用化合物的波谱数据鉴定其结构。结果从枸骨叶的氯仿部位分得11个脂溶性成分,其中包括7个三萜类成分即羽扇豆醇(1),11-酮基-α-香树脂醇棕榈酸酯(Ⅱ),α-香树脂醇棕榈酸酯(Ⅲ),3,28-乌索酸二醇(Ⅳ),熊果酸(Ⅴ),30-醛基羽扇豆醇(Ⅵ),30-酮基降羽扇豆醇(Ⅶ);1个链状倍半萜tanacetene(Ⅷ);1个甾醇β-谷甾醇(Ⅸ),2个有机酸类成分即正二十二烷酸(Ⅹ)和正二十六烷(Ⅺ)。结论化合物Ⅳ,Ⅶ,Ⅷ,Ⅹ和Ⅺ为首此从冬青属植物中分得,化合物Ⅱ,Ⅲ和Ⅸ为首次从该植物中分得。倍半萜类成分为首此从冬青属植物中分得的化合物类型。OBJECTIVE To investigate the liposoluble components from the leaves of llex cornuta Lindl. ex Paxt..METHODS The compounds were isolated by repeated column chromatography on silica gel and Sephadex LH - 20, and the structures were elucidated by spectral analysis.RFSULTS Eleven compounds were obtained. Their structures were identified as lupeol（Ⅰ）, 11-keto-α-amyrin palmitate（Ⅱ）, a-amyrin palmitate（Ⅲ）, 12-msene-3,28-diol（Ⅳ）, ursolic acid（Ⅴ）, 3β-hydmxylup-20（29）-en-30-al（Ⅵ）, 3β-hydmxy-20-oxo-30-norlupane（Ⅶ）, tanacetene（Ⅷ）,β-sitosteml（Ⅸ）, n-behenic acid（Ⅹ）, and n-hexacosane（Ⅺ）.CONCLUSION Compound Ⅳ, Ⅶ, Ⅷ, Ⅹ and Ⅺ are firstly isolated from the genus llex. In addition, compound Ⅱ ,Ⅲ and Ⅳ are. isolated from I. cornuta for the first time.

关 键 词：枸骨叶 脂溶性成分 三萜 

分 类 号：R284.2[医药卫生—中药学]