正常红细胞与血管内皮细胞粘附特性  

PROPERTIES OF VASCULAR ENDOTHELIAL ADHERENCE OF NORMAL ERYTHROCYTE 

作　　者：陈槐卿[1] 丁肇华 王玲[1] 黄勋[1] 

机构地区：[1]华西医科大学生物医学工程研究室

出　　处：《中国生物医学工程学报》1996年第2期170-175,共6页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金;纽约中华医学基金会

摘　　要：用流室法研究正常红细胞（ＲＢＣ）与人工培养的脐静脉内皮细胞之间的粘附特性。结果表明在低切应力下，正常红细胞与内皮细胞之间存在一定数量的粘附，随着切应力的逐步增大，ＲＢＣ—内皮细胞的粘附越来越减少。自体血浆的参与能增加ＲＢＣ—内皮细胞之间的粘附数量约３～５倍，并且也增强了粘附的强度。本文给出了反映切应力与ＲＢＣ—内皮细胞粘附数关系的经验公式，得到粘附特征参数ａ，ｂ值。此ａ，ｂ值能反映不同条件下的ＲＢＣ—内皮细胞粘附特性，本文结果还提出，在体内微静脉部位。Using a flow chamber, we studied the properties of normal erythrocyte adherence to cultured human umbilical vein endithelial cells. The results showed that a number of normal erythrocytes adhered to endothelial cells at low shear stress. With gradual increase of shear stress, the erythrocyte endothelial adherence became less and less. Autologous plasma could increase the number of the erythrocyte endothelial adhesions by 3-5 times as well as adherence strength. The empirical equations were given representing relationship between shear stress and numer of RBC-endithelial adherence. Using these equations, the adhesion characteristic parameters a and b could be calculated. The values of a and b could reflect the properties of RBC-endothelial adherence under different conditions. Therefore, it could be speculated that in vivo normal erythrocyte endothelial adhesions might occur in venules of microcirculation.

关 键 词：红细胞 血管内皮细胞 粘附 细胞流变学 

分 类 号：R318.01[医药卫生—生物医学工程]