可降解聚天冬氨酸水凝胶的制备与应用研究  

Preparation and Behavior of Biodegradable Hydrogels based on Poly-aspartic Acid

作　　者：吴军[1] 陈强[1] 李利[2] 杨溢[1] 朱瑞[1] 沈健[1] 林思聪[1] 

机构地区：[1]南京大学化学化工学院 [2]江苏省生物医药功能材料技术研究中心,南京师范大学南京210097

出　　处：《材料导报》2005年第10期126-128,共3页Materials Reports

基　　金：江苏省高技术研究项目(2002HXXSB98222);江苏省科技厅项目(BG2002018);江苏省教育厅项目(JHjd03-008;JH03-013);南京大学分析测试基金资助

摘　　要：以天冬氨酸为原料,合成了聚丁二酰亚胺(PSI);采用氨基封端的聚乙二醇作为交联剂制备出了聚天冬酰胺水凝胶;研究了聚丁二酰亚胺分子量、交联剂分子量以及交联剂的用量等因素对水凝胶溶胀性能的影响,并研究了以甲硝唑为模型药物,在37℃下、pH=4.6的介质中,药物在聚天冬酰胺水凝胶中的控制释放。Poly （scccinimide） based on aspartic acid is crosslinked by PEG-diamine to form water swelling hydrogels possessing a three dimensional molecular network. The hydrogels network structure is characterized by FT-IR and swelling measurements. Research result shows the effect of molecular weight of PSI, molecular weight of cross linker and amount of cross linker on swelling behavior of hydrogels. Metronidazole is chosen as drug-model, drug release from the hydrogels loaded by the soaking method takes place in less than 8h; On the contrary, samples loaded during crossing reaction release the same amount as that loaded by the soaking method in 13 days.

关 键 词：聚天冬酰胺 水凝胶 氨基封端的聚乙二醇 控制释放 甲硝唑 聚天冬氨酸 制备 可降解 聚丁二酰亚胺 应用 

分 类 号：TQ085.4[化学工程] O648.17[理学—物理化学]