染料木素磺酸钠制备及其抗脂质过氧化作用  

Preparation of Natrium Sulfogenisteinates and Their Anti Peroxidation Activity for Lipids

作　　者：索志荣[1] 张尊听[2] 郑建斌[1] 

机构地区：[1]西北大学分析科学研究所/陕西省电分析化学重点实验室,西安710069 [2]陕西师范大学化学与材料科学学院

出　　处：《应用化学》2005年第10期1083-1086,共4页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(20275030);陕西省自然科学基金(2004B20);西北大学中青年基金(03NW29)资助项目

摘　　要：染料木素(G)是具有明显的抗肿瘤、降血脂、抗动脉粥样硬化等活性的异黄酮类化合物,其脂溶性和水溶性均较差,生物利用度不高。通过对其磺化,合成了它的3′-磺酸钠(G1)和3,′6-二磺酸钠(G2)2种水溶性衍生物,用IR、1H NMR等测试技术对其结构进行了表征,比较了G、G1和G2的抑制脂质体过氧化作用。结果表明,G1和G2的抗氧化活性强于G。Genistein （G） has the effects of anti-tumour and anti-arteriosclerosis. It can also reduce plasma lipid and kill various cancer cells without damaging the normal cells. Nevertheless, its medical application is much restricted because of its poor solubility in water and fat. In this study, its two new water-soluble deriva- tives, genistein-3＇-sodium sulfonate （ G1 ） and genistein-3＇, 6-disodium sulfonate （ G2 ）, were prepared via sulfation and column chromatography separation. The structures of the two compounds were identified by means of IR and ^1H NMR. At the same time, the inhibitory ratios of G, G1 and G2 against lipid peroxidation were determined. The results show that G1 and G2 not only have stronger anti-peroxidation activity for lipids than G, but also have good water solubilities.

关 键 词：染料木素 染料木素磺酸钠 水溶性 抗脂质体过氧化 

分 类 号：O614[理学—无机化学]