香豆素类抗凝血药及其类似物的合成  

Synthesis of Coumarin Anticoagulant and Its Analogues

作　　者：申东升[1] 刘小帆[2] 杨广照[2] 

机构地区：[1]广东药学院药科学院,广州510006 [2]湘潭大学化学学院,湘潭411105

出　　处：《应用化学》2005年第10期1158-1160,共3页Chinese Journal of Applied Chemistry

摘　　要：The condensation reaction of 4-hydroxycoumarin with each of ah substituted benzalacetones in（absolute） ethanol gave coumarin analogues which were subsequently converted to their ethyl ethers（cyclocou-（marin））.The ethers can be quantitatively converted back to the coumarin analogues by acid hydrolysis.Four of them are new substances.The reaction mechanism is discussed in detail.All the products were characterized by HPLC,IR and 1H NMR.Compared with the present process in the literature,the process for the synthesis of the coumarin analogues is obviously improved on the reaction time,temperature,solvent,（catalyst）,and post-treatment.The condensation reaction of 4-hydroxycoumarin with each of a-h substituted benzalacetones in absolute ethanol gave coumarin analogues which were subsequently converted to their ethyl ethers （cyclocoumatin）. The ethers can be quantitatively converted back to the coumarin analogues by acid hydrolysis. Four of them are new substances. The reaction mechanism is discussed in detail. All the products were characterized by HPLC, IR and ^1H NMR. Compared with the present process in the literature, the process for the synthesis of the coumarin analogues is obviously improved on the reaction time, temperature, solvent, catalyst, and post-treatment.

关 键 词：羟基香豆素 取代苯丁烯酮 缩合 香豆素类似物 

分 类 号：O625.4[理学—有机化学]