载脂蛋白E基因多态性与自杀未遂关系的研究  

Study on association between gene polymorphism of Apolipoprotein E and attempted suicide

作　　者：贾存显[1] 赵仲堂[1] 高莉洁[1] 汪心婷[1] 郝凤荣[1] 

机构地区：[1]山东大学公共卫生学院流行病与卫生统计学研究所,济南250012

出　　处：《中国公共卫生》2005年第10期1184-1185,共2页Chinese Journal of Public Health

基　　金：山东省自然科学基金(21320005200262);山东大学校青年基金(21320053187059)

摘　　要：目的探讨载脂蛋白E(Apo E)基因多态性与自杀未遂的关系。方法采用配对病例对照与聚合酶链反应和限制性片段长度多态性(PCR-RFLP)方法对220对自杀未遂者及对照进行分析。结果自杀未遂者中存在ApoE4种基因型,分别为Apo E-E2/3,E3/3,E2/4和E3/4,其中以Apo E-E3/3为主。经多状态模型分析影响不同基因型自杀未遂(Apo E-E2/3、E3/3、E2/4均相对于E3/4基因型)的因素,发现情感冲突、对现在生活不满意与E2/4基因型相关,情感冲突与E2/3基因型相关,没有发现与E3/3型相关的因素。经条件Logistic回归模型分析未发现不同Apo E基因型与自杀未遂相关联。结论本研究不支持Apo E基因与自杀未遂相关联,但不同Apo E基因型自杀未遂的影响因素不同。Objective To understand the association between gene polymorphism of apolipoprotein E （Apo E）and attempted suicide. Methods 220 paired suicide attempted and controls were analyzed by polymerase chain reaction and restriction fragment length polymorphism （PCR - RFLP）. Results There were four gene types of Apo E in each suicide attempters and controls group which were Apo E - E2/3, E3/3, E2/4 and E3/4 and in which Apo E - E3/3 was the main type. Multinomial model was used to analyze the factors which were related with attempted suicide with different Apo E gene type（attempters with Apo E - E3/4 being reference group）, the results showed that affective conflict and dissatisfaction with life now were associated with attempters with Apo E - E3/3, affective conflict were also associated with attempters with Apo E - E2/ 3, and no factors were associated with attempters with Apo E - E3/3. There were no association between different gene types of Apo E and attempted suicide by conditional logistic regression analysis. Conclusion This study didn＇t support the association between Apo E gene and attempted suicide. There were different factors related with suicide attempters with different gene type of Apo E.

关 键 词：自杀未遂 载脂蛋白E 基因 流行病学 

分 类 号：R181.37[医药卫生—流行病学]