尼群地平对缺氧性右心室肥大的预防和治疗作用(英文)  

Preventive and therapeutic effects of nitrendipine on hypoxic right ventricular hypertrophy

作　　者：谢增柱[1] 刘福玉[1] 王仕军 万强[1] 仇玉福[1] 

机构地区：[1]第三军医大学高原医学研究所

出　　处：《中国药理学报》1996年第4期337-340,共4页Acta Pharmacologica Sinica

摘　　要：目的:本文探讨尼群地平对缺氧性右心室肥大的影响。方法:慢性间断性减压引起缺氧性右心室肥大,用右心室重量指数,心肌超微结构变化来评价尼群地平疗效。结果:慢性缺氧大鼠右心室收缩压及右心室重量指数明显增加及心肌超微结构变化。无论在减压开始或已发展右心室肥大后,服用尼群地平均可降低右室收缩压和右室重量指数及促使心肌超微结构正常。结论:尼群地平可预防和减轻缺氧性右心室肥大。AIM: To assess whether nitrendipine (Nit) can be used to prevent and treat the hypoxic right ventricular hypertrophy (RVH). METHODS: Rats were exposed to a simulated altitude of 5000 m (barometric pressure = 54 kPa) for 30-60 d. Nit (10-20 mg·kg-1·d-1) was administered via gavage. The therapeutic efficacy was evaluated with right ventricular weight index (RVWI), right ventricular systolic pressure ( RVSP ), and myocardial ultrastructure. RESULTS: Chronic intermittent hypoxia for 30 d (8 h·d-1) resulted in an increase of RVSP and RVWI as well as in the changes of RV myocardial ultrastructure. As the hypoxic time was prolonged to 60 d, RVWI and RVSP were not further augmented. Nit (20 mg ·kg-1 · d-1, ig), when administered from the beginning of hypoxia, reduced RVSP (8.1 ± 1.1 vs 6.0± 1.0 kPa, P<0.05) and RVWI (1.014 ±0.012 vs 0.915±0.049 mg/g body weight, P <0.05). After development of hypoxic RVH, Nit (20 mg·kg-1) also decreased RVSP (7.9± 1.0 vs 6.2 ±0.8 kPa, P<0.05) and RVWI (1.02 ±0.13 vs 0.88 ±0.12 g/kg body weight, P< 0.05). Myocardial blood flow was increased and myocardial ultrastructure became nearly normal in rats treated with Nit. CONCLUSION: Nit prevented and lessened the hypoxic right ventricular hypertrophy.

关 键 词：缺氧症 右心室肥大 尼群地平 预防 治疗 

分 类 号：R541.05[医药卫生—心血管疾病] R972[医药卫生—内科学]