抗氧化剂对2型糖尿病人C-反应蛋白和IL-6表达的影响  

EFFECTS OF COMBINED ANTIOXIDANTS ON THE EXPRESSION OF CRP AND IL-6 IN TYPE 2 DIABETIC PATIENTS

作　　者：郭松超[1] 朱翠凤[2] 曾志励[1] 吴清香[2] 罗佐杰[1] 

机构地区：[1]广西医科大学,南宁530021 [2]广东省深圳市北京大学深圳医院,深圳518036

出　　处：《营养学报》2005年第5期374-377,共4页Acta Nutrimenta Sinica

基　　金：广西科技厅科技攻关项目(桂科攻No.0322025-6)

摘　　要：目的:观察大豆异黄酮和维生素C(VC)、维生素E(VE)复合抗氧化剂对2型糖尿病(type2diabeticpatients,DM)患者急性高血糖状态下急性时相反应蛋白C(acuteCreactiveprotein,CRP)和白细胞介素6(IL-6)表达调节作用。方法:选择96例DM患者随机分为4组,DM对照组(B),低(C)、中(D)、高(E)剂量复合抗氧化剂组。复合抗氧化剂为大豆异黄酮、VC和VE的混合物。另选24名健康对象为正常对照组(A)。进行口服葡萄糖耐量试验(oralglucosetolerancetest,OGTT),观察各组在0、1、2、4、6h血清中CRP和IL-6的变化。结果:DM组和C组CRP和IL-6水平于OGTT后1h达峰值,显著高于OGTT0h(P<0.05)D组女性和E组OGTT后1hCRP和IL-6水平显著低于OGTT0h(P<0.05)。结论:一定剂量的复合抗氧化剂可抑制2型DM患者CRP和IL-6的表达,女性可能较男性更为敏感。Objective： To investigate the effects of the cooperative actions of isoflavone, vitamin C and E on the expression of acute C reactive protein （CRP） and interleukin 6 （IL-6） in the patients with type II diabetic mellitus （DM）. Method： Ninety six patients with DM were divided randomly into 4 groups, DM control group（B）, and groups receiving low（C）, medium （D）, and high （E） dose of the compound antioxidant of isoflavone, vitamin C and E respectively. Another 24 healthy subjects served as normal control group （A）. Observe the changes of the levels of CRP and IL-6 during oral glucose tolerance test （OGTT）. Results： The peak of serum levels of CRP and IL-6 in the patients of DM control group and lower dosage group appeared 1 h after OGTT and were significantly higher than the 0 h value （P 〈0.05）. The levels of CRP and IL-6 in the patients of high dosage group and medium dosage female group 1 h after OGTT were significantly lower than the 0 h value （P〈0.05）. Conclusion： The combined antioxidants of isoflavone, vitamin C and E can inhibit the serum levers of CRP and IL-6, during OGTT and was more sensitive in female.

关 键 词：抗氧化剂 C反应蛋白 白细胞介素6 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]