儿科血分离菌株及其抗生素敏感性的研究  

Study on frequency of occurrence and antimicrobial susceptibility of bacteria isolated from blood in pediatric patients

作　　者：赖晓全[1] 王洪波[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院感染科,430030

出　　处：《中国妇幼保健》2005年第20期2711-2713,共3页Maternal and Child Health Care of China

摘　　要：目的:了解儿科血分离菌株及其抗生素敏感性特点.方法:湖北地区15所医院1999～2003年临床儿科血分离菌株用纸片扩散法进行药敏试验.结果:儿科血分离菌株最常见的前6位病原菌是凝固酶阴性葡萄球菌(54.8%)、金黄色葡萄球菌(16.1%)、伤寒沙门菌(6.5%)、肠球菌(2.7%)、大肠埃希菌(1.8%)和克雷伯菌属(1.7%).万古霉素是G+菌最为敏感的抗生素,其次是头孢唑啉;亚胺培南对G-菌最敏感,其次为头孢他啶.结论:儿科菌血症以G+菌感染为主,临床抗生素经验用药应以当地的细菌耐药性监测资料为依据.Objective： To study the frequency of occurrence and antimicrobial susceptibility of bacteria isolated from blood in pediatric patients. Methods ： Antimicrobial susceptibility of all bloodstream strains of pediatric patients isolated from 1999 to 2003 in 15 hospitals in Hubei province were testd by disc diffusion methodology. Results： The six most frequently isolated species were： coagulase - negative staphylococci （54.8%）, staphylococcus aureus （16. 1%）, S. typhi （6.5%）, enterococci （2.7%）, E. coli （1.8%） and klebsiella sp. （ 1.7% ） . Vancomycin was the most effective antibiotic against Gram - positive organisms, which was followed by cefazolin. Imi＇penem was the most effective antibiotic against Gram - negative organisms, which was followed by ceftazidime. Conclusion： Gram - positive organisms are frequent and predominate in children bacteremia. The empirical antibiotics treatment should be based on the information of surveillance of microbial pathogens and their drug - resistance in local area.

关 键 词：儿童 菌血症 细菌 耐药性 

分 类 号：R725[医药卫生—儿科]