正交试验优选复方环丙沙星凝胶基质组成及制备工艺  被引量:4

Optimization of Base Material Compositions of Compound Ciprofloxacin Gel by Orthogonal Test and Its Preparation Technology

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作  者:刘铭佩[1] 李芳[1] 焦海胜[1] 朱恒[1] 王爱兰[2] 梁晓东[2] 

机构地区:[1]兰州大学第二医院药剂科,兰州市730030 [2]兰州医学院药学系,兰州市730030

出  处:《中国药房》2005年第19期1456-1458,共3页China Pharmacy

摘  要:目的:优选复方环丙沙星凝胶基质组成及制备工艺。方法:选取盐酸环丙沙星、卡波姆-940、甘油、三乙醇胺处方用量4种因素为可变因素,以成品稳定性为考察指标,选用L9(34)表进行正交试验。结果:最优的基质组成及工艺为盐酸环丙沙星0.3%、卡波姆-9401%、甘油7.5%、三乙醇胺2%。结论:按优选工艺制备的凝胶符合《中国药典》2000年版规定。OBJECTIVE: To optimize base material compositions and preparation technology for compound ciprofloxacin gel.METHODS: 4 factors, ciprofloxacin, carbomer- 940, glycerine, triethanolamine(in formula dosages) were selected as variable factors, the stability of the preparation was taken as the index for investigation and table L9(3^4) was used to conduct the orthogonal experiment. RESULTS: The optimum base material composition and technology were the following, ciprofloxacin 0.3 %, carbomer - 940 1%, glycerine 7.5 %, triethanolamine 2 %. CONCLUSION : The compound ciprofloxacin gel prepared based on the optimized technology is in conformity with the specification stated in Chinese Pharmacopoeia (2000).

关 键 词:正交试验 盐酸环丙沙星 凝胶 卡波姆-940 

分 类 号:TQ460.6[化学工程—制药化工] R944.15[医药卫生—药剂学]

 

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