结缔组织生长因子在慢性乙型肝炎和肝硬化组织中的表达及意义  

作　　者：汪明明[1] 崔速南[1] 李新立[1] 杨公炜[1] 张秀珍[1] 杜文军[1] 

机构地区：[1]济南市传染病医院,山东济南250021

出　　处：《山东医药》2005年第29期17-18,共2页Shandong Medical Journal

基　　金：济南市卫生局立项课题(2003-25)

摘　　要：目的探讨结缔组织生长因子(CTGF)的肝内表达与肝纤维化或肝硬化的关系。方法对93例慢性乙型肝炎和肝炎肝硬化的肝组织活检标本采用免疫组化方法进行CTGF肝内表达研究,比较分析慢性乙型肝炎和肝炎肝硬化的CTGF肝内表达及表达的细胞定位。结果肝炎肝硬化CTGF的表达强度明显高于慢性乙型肝炎(P<0.01);CTGF的表达与慢性乙型肝炎的炎性活动明显相关(P<0.05);CTGF的表达主要集中于汇管区和纤维化区,肝星状细胞、成纤维细胞和窦状隙内皮细胞染色阳性。结论CTGF的表达在肝纤维化和肝硬化中发挥着重要作用,肝星状细胞、成纤维细胞和窦状隙内皮细胞是肝内CTGF的重要来源。Objective：To explore the relationship between the expression of connective tissue growth factor （CTGF） and liver fibrosis or cirrhosis due to hepatitis B virus infection. Methods： Ninety three samples of cirrhosis of liver or chronic hepatitis B （CHB） was enrolled in the study. Intrahepatic expression of CTGF was assayed by immunohistochemical staining. Results：Expression of CTGF in cirrhosis of liver was significantly stronger than that in CHB （P〈0.01）, and was correlated with inflammation of hepatic tissue （P〈0.05）. Expression of CTGF was observed in portal tracts and fibrous septa predominantly in the fibrogenesis areas. The positive staining was observed in hepatic stellate cells, sinusoidal endothelial cells and fibroblasts. Conclusions： Intrahepatic expression of CTGF play an important role in pathogenesis of fibrosis or cirrhosis. Hepatic stellate Cells, sinusoidal endothelial cells and fibroblasts seem to be the major cellular sources of CTGF in the liver.

关 键 词：结缔组织生长因子 肝内表达 肝炎肝硬化 免疫组化染色 

分 类 号：R512.6[医药卫生—内科学]