SEDS技术制备水飞蓟素纳米颗粒  

Preparation of Silymain Nanoparticles by SEDS Technique

作　　者：于文利[1] 陈蓓怡[1] 赵亚平[1] 蒋思媛[1] 

机构地区：[1]上海交通大学化学化工学院,上海200240

出　　处：《高校化学工程学报》2005年第5期695-698,共4页Journal of Chemical Engineering of Chinese Universities

基　　金：上海市科委纳米专项(0243nm097)。

摘　　要：采用超临界流体增强溶液分散技术(SEDS)从丙酮溶液中沉淀制备水飞蓟素纳米颗粒,用扫描电镜考察了工艺参数温度(25℃,32℃,40℃,50℃)、压力(9.5 MPa,12 MPa,15 MPa,20 MPa)、溶液浓度(40 mg·mL-1,60 mg·mL-1,80mg·mL-1,100 mg·mL-1,120 mg·mL-1)对颗粒形貌、粒径尺寸及粒径尺寸分布的影响.结果表明,所得颗粒均为实心微球;温度和溶液浓度是影响粒径尺寸的主要因素,降低温度和浓度能够显著减小粒径尺寸;温度也对粒径尺寸分布影响显著,在40℃时,粒径尺寸分布较窄,当温度高于或低于40℃时,粒径尺寸分布明显变宽.通过优化工艺参数,在9.5 MPa,40℃,60 mg·mL-1的条件下,制备出粒径尺寸介于100～300nm的水飞蓟素纳米颗粒.The solution enhanced dispersion by supercritical fluid （SEDS） technique was used to precipitate silymarin nanoparticles from an organic solution of acetone. The effects of process parameters, such as temperature, pressure, and solution concentration on morphology, particle size （PS）, and particle size distribution （PSD） of the particles gained were investigated by using scanning electron microscope （SEM）. Results show that all particles are solid mierosphere, and that the temperature and solution concentration are the main influence factors on PS. The reduction of temperature and concentration leads to PS decrease significantly, and temperature also affects PSD significantly. PSD is narrow at temperature 40℃, and it becomes wider when temperature is higher or lower than 40℃. Through optimization of process parameters, silymarin particles of 100～300 nm in diameter can be obtained at 9.5 MPa, 40℃ and solution concentration 60 mg·mL^-1.

关 键 词：超临界流体 水飞蓟素 纳米颗粒 微细化 SEDS 

分 类 号：O643.36[理学—物理化学] TQ426.6[理学—化学]