^(99)Tc^m示踪观察rt-PA对家兔脑卒中模型的溶栓效果  

Thrombolytic Efficacy of rt-PA in Embolic Stroke of Rabbits by ^(99)Tc^m Trace

作　　者：于冰[1] 仝健[1] 李怀芬[1] 

机构地区：[1]中国医学科学院中国协和医科大学放射医学研究所,天津300192

出　　处：《同位素》2005年第3期160-163,共4页Journal of Isotopes

摘　　要：采用颈内动脉注射自体全血凝块形成家兔栓塞性脑卒中模型,应用99Tcm体内动态示踪,研究重组组织型纤溶酶原激活剂(Recombinant Tissue Plasminogen Activator,rt-PA)治疗血栓引起的栓塞性脑卒中的有效性。结果表明,在家兔栓塞性脑卒中模型上,静脉给予0.5、1 mg/kg rt-PA,能产生显著的渐进性溶栓作用。It is established that rabbit model of embolic stroke by injecting its thrombus into internal carotid. The therapy effect of recombinant tissue plasminogen activator（rt-PA） is studied by ^99Tc^m trace. The results indicat that the thrombolytic efficacy of rt-PA is potent when the rabbit model of embolic stroke treated is with 0. 5,1 mg/kg rt-PA.

关 键 词：^99Tc^m示踪 纤溶酶原激活剂(rt-PA) 脑卒中 溶栓效果 

分 类 号：R817.4[医药卫生—影像医学与核医学]