HPLC/ELSD指纹图谱和星座图聚类法在清开灵注射液质量评价中的应用  

Application of HPLC/ELSD fingerprint and constellation graphical clustering method applied to evaluate the quality of Qingkailing injection

作　　者：严诗楷[1,2] 辛文锋[3,4] 王义明[3] 罗国安[3] 程翼宇[1] 

机构地区：[1]浙江大学药学院中药科学与工程学系 [2]清华大学药物研究所,北京100084 [3]清华大学药物研究所 [4]江西中医学院,江西南昌330006

出　　处：《药学学报》2005年第9期842-845,共4页Acta Pharmaceutica Sinica

基　　金：国家973重点基础研究资助项目(G1999054404);科技部重大专项资助项目(2002BA906A293).

摘　　要：目的对清开灵注射液的质量进行科学评价,为有效控制中药质量提供一种可靠方法。方法采用HPLC/ELSD指纹图谱技术结合星座图聚类法,测定不同厂家的18个批次清开灵注射液的指纹图谱,并评价产品质量。结果本法直观、准确地表达了产品的质量信息。结论本法是中药质量评价的一种直观、合理、有效的技术手段。Aim To evaluate the quality of Qingkailing injections credible method for the quality control of traditional Chinese medicine. Qingkailing injection samples from various manufacturers were obtained evaluation was performed by constellation graphical clustering method. effectively, and to develop a Methods Fingerprints of 18 by HPLC/ELSD, and quality Results HPLC/ELSD and constellation graphical clustering method properly revealed the quality information apparently and accurately. Conclusion It was an apparent, credible and efficient method for quality evaluation of Chinese medicines.

关 键 词：高效液相色谱 蒸发光散射 星座图聚类法 指纹图谱 清开灵注射液 

分 类 号：R917[医药卫生—药物分析学]