基质金属蛋白酶在分娩中的表达及其意义  

Expression and effect of matrix metalloproteinases during delivery

作　　者：王凤英[1] 陈升平[1] 祝诚[2] 林海燕[2] 刘维靖[1] 王冬娜[1] 谢峰[1] 张海珍[1] 

机构地区：[1]首都医科大学宣武医院妇产科,100053 [2]中国科学院动物研究所国家重点实验室生殖生理组

出　　处：《北京医学》2005年第10期603-605,共3页Beijing Medical Journal

摘　　要：目的探讨基质金属蛋白酶在分娩机制中的作用。方法采用蛋白电泳法测定40例(自然分娩和剖宫产各20例)血清基质金属蛋白酶!2(MMP!2)、基质金属蛋白酶!9(MMP!9)蛋白的活性变化及表达情况。结果自然分娩组和剖宫产组MMP!9酶原形式的表达分别为14970.33±1891.20和11626.80±2161.75,MMP!9活性形式分别为35523.17±6820.10和25972.13±4615.03;MMP!2酶原形式分别为19858.40±4030.78和12542.33±1607.20,MMP!2的活性形式分别为26909.33±2976.38和15120.50±2421.03。自然分娩组和剖宫产组比较均具有显著性差异(P<0.05)。结论MMP!9和MMP!2蛋白在自然分娩中表达高于剖宫产,提示自然分娩MMP!9和MMP!2蛋白使宫颈的胶原分解,并促使宫颈成熟和扩张。Objective To determine the value of matrix metalloproteinases-2,-9 in plasma in order to evaluate the effect of matrix metalloproteinases in delivery stir mechanism. Methods Albumen electophoresis technique was used to determine the value of MMP-2, MMP-9 in 40 cases （caesarean birth and vagina labour ） plasma. Results The MMP-9 zymogen formal expression in vagina labour group and caesarean birth group was 14970.33±1891.20 and 11626.80±2161.75. Respectively while the MMP-9 alive formal expression was 35523.17±6820.10 and 25972.13±4615.03 respectively. The MMP-2 zymogen formal expression was 19858.40±4030.78 and 12542.33±1607.20. Respectively and the MMP-2 alive formal expression was 26909.33±2976.38 and 15120.50±2421.03 respectively. There was significant difference in two groups （P〈0.05）. Conclusions MMP-2, MMP-9 protein expression is higher in vagina labour group than in caesarean birth group. This suggests that MMP-2, MMP-9 protein whict can promote cervical mature and expand in vagina labour is decomposed subsequently to spur ceruical postern.

关 键 词：基质金属蛋白酶 自然分娩 剖宫产 基质金属蛋白酶-2(MMP-2) 基质金属蛋白酶-9(MMP-9) 分娩机制 MMP-2蛋白 其意义 MMP-9活性 活性变化 

分 类 号：R714.1[医药卫生—妇产科学]