甲基黄酮醇胺抗血栓形成的机理研究  

Study on antithrombosis mechanism of methylflavonolamine

作　　者：郝一彬[1,2] 李锦平[1,2] 周尔凤[1,2] 

机构地区：[1]山西医学院药理学教研室 [2]山西医学院汾阳专科部

出　　处：《山西医学院学报》1996年第3期169-171,共3页

摘　　要：采用生物鉴定法测定甲基黄酮醇胺（ＭＦＡ）对ＰＧＩ２和ＴＸＡ２样物质生成的影响。以血小板聚集率％表示大鼠颈总动脉环ＰＧＩ２活性，ＭＦＡ（２４．８μｍｏｌ／ｋｇ，ｉｖ）组，阿斯匹林（ＡＳＡ，０．８３ｍｍｏｌ／ｋｇ，ｉｖ）组和溶媒对照组分别为０．４７±０．１９、０．１８±０．１６、０．５０±０．１３／ｍｇ，结果提示：ＭＦＡ不抑制ＴＸＡ２的生成（Ｐ＜０．０５）；ＡＳＡ明显抑制ＰＧＩ２的生成（Ｐ＜０．０１）。采用表面灌流法，ＡＡ为诱导剂，以兔主动脉条收缩强度（ｇ）表示ＴＸＡ２样物质的活性，ＭＦＡ（１０ｍｍｏｌ／Ｌ）组，咪唑（１．６７ｍｍｏｌ／Ｌ）组和溶媒对照组分别为０．３８±０．１３、０．１７±０．０９和０．６９±０．２２ｇ，结果提示ＭＦＡ和咪唑抑制ＴＸＡ２样物质的生成（Ｐ＜０．０１）。采用放射免疫法测定，ＭＦＡ６．２μｍｏｌ或１２．４μｍｏｌ／ｋｇ能明显抑制心肌梗塞家兔ＴＸＢ２的升高（Ｐ＜０．０１）。Effect of methylflavonolamine (MFA) on modulation of PGI 2 TXA 2 balance were studied, MFA 24 8μmol/kg iv did not inhibit the generation of PGI 2 like substance from rat carotid arterial wall.MFA 10mmol/L inhibited the generation of TXA 2 like substance from guinea pig lung induced by arachidonic acid.The radioimmunoassay showed that MFA 6 2 or 12 4μmol/kg iv significantly inhibited the elevation of plasma TXB 2 during myocardial infarction in rabbits,while did not affect the level of plasma 6 keto PGF 1 .These results suggest that MFA may play a beneficial role to modulation of PGI 2 TXA 2 balance.

关 键 词：甲基黄酮醇胺 前列腺素I2 血栓素A2 

分 类 号：R965.1[医药卫生—药理学] R973.2[医药卫生—药学]