2型糖尿病患者尿白蛋白排泄率与血栓调节蛋白的相关性  

Correlation between urinary albumin excretion rate and levels of thrombombdulin in type 2 diabetes patients

作　　者：周力[1] 曹卫华[1] 张爱华[1] 徐丽华[1] 黄丽红[1] 

机构地区：[1]潍坊医学院形态诊断学教研室,山东省潍坊市261042

出　　处：《中国临床康复》2005年第31期86-87,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:探讨反映2型糖尿病患者微血管病变的尿白蛋白排泄率与血栓调节蛋白以及血小板计数的关系。方法:纳入潍坊医学院附属医院内分泌科2000-01/2004-12住院的型糖尿病患者68例。于次晨8时收集血浆及24h尿标本,检测2型糖尿病患者尿白蛋白排泄率,根据尿白蛋白排泄率分为3组:无白蛋白尿组(<30mg/L)23例、微量白蛋白尿组(30～299mg/L)21例、临床白蛋白尿组(≥300mg/L)24例。纳入潍坊医学院附属医院同期健康体检者30例为对照组,同2型糖尿病患者一样收集血液及尿液标本,检测4组血浆血栓调节蛋白。参与者知情同意。用SPSSforwindow11.5统计软件作回归线性分析。结果:2型糖尿病患者68例和健康体检者30例均进入结果分析。①对照组、无白蛋白尿组、微量白蛋白尿组、临床白蛋白尿组的尿白蛋白排泄率分别为(13.35±4.2),(15.45±5.4),(190.5±18),(555±21)mg/L;血栓调节蛋白分别为(12±4.7),(21±5.2),(45±4.5),(75±5.5)μg/L。②尿白蛋白排泄率与血浆血栓调节蛋白含量呈正相关(r=0.978,P=0.022)。③与血小板计数的关系:2型糖尿病患者无蛋白尿组血浆血栓调节蛋白水平明显高于正常对照组,血浆血栓调节蛋白水平与尿蛋白排泄率及血小板计数均呈现显著正相关。结论:2型糖尿病患者尿白蛋白排泄率与血浆血栓调节蛋白含量水平呈相关,提示2型糖尿病患者出现并发症之前就已可能存在微血管病变。因此,早期检测2型糖尿病患者尿白蛋白排泄率和血浆血栓调节蛋白,有助于延缓2型糖尿病血管并发症的发生与发展。AIM： To explore the relationship of urinary albumin excretion rate （UAER） and levels of thrombombdulin of microvessel lesion with platelet count in type 2 diabetes patients. METHODS： Sixty-eight inpatients with type 2 diabetes from Department of Endocrinology, Affiliated Hospital, Weifang Medical College from January 2000 to December 2004 were included. The plasm and 24 hours urine sample were collected at 8：00 in the morning of the following day. The UAER was assayed in the type 2 diabetes patients. According to the UAER they were assigned into 3 groups： non-albuminuria group （ 〈 30 mg/L） with 23 cases, microalbuminuria group （30-99 g/L）with 21 cases and clinical albuminuria group （≥ 300 g/L） with 24 cases. The 30 healthy testees at synchronization examined in the Affiliated Hospital, Weifang Medical College were involved as control group. The blood and urine sample were also collected as the type 2 diabetes patients. The plasm thrombombdulin of the four groups was detected. The participators were agreed and knew the factors. The linear regression analysis was conducted by SPSS for window 11.5 statistics software. RESULTS： Totally 68 patients with type 2 diabetes and 30 healthy people were involved in the result analysis. ① In the control group, nonalbuminuria group, microalbuminuria group and clinical albuminuria group, the UAER were （13.35±4.2）, （ 15.45±5.4）, （ 190.5±18）, （555±21） mg/L, respectively. The thrombombdulin was （12±4.7）, （21±5.2）, （45±4.5）, （75±5.5） μg/L, respectively. ② There were positive correlation of the content of urinary albumin excretion rate and levels of thrombombdulin （r =0.978, P=0.022）. ③ Relationship with platelet count： The level of thrombombdulin in the non-proteinuria group of the type 2 diabetes patients was significantly higher than that in the normal control group. There was significantly positive correlation of the level of thrombombdulin and UAER with platelet count. CONCLUSION： The UAER has r

关 键 词：糖尿病 白蛋白 血栓调节蛋白 

分 类 号：R587.1[医药卫生—内分泌]