大豆总皂甙在中枢引起的心血管效应及其与单胺类递质的关系  

Cardiovascular effects of total soyasaponin in central nervous system and its relationship with monoamine transmitters

作　　者：郭建晖[1] 唐毓环[1] 卫永弟[1] 李建华[1] 赵华[1] 王绍[1] 

机构地区：[1]白求恩医科大学生物化学教研室 生理教研室

出　　处：《中国药理学报》1996年第3期239-241,共3页Acta Pharmacologica Sinica

摘　　要：并用高压液相电化学检测法和荧光法测定端脑、间脑、脑干的单胺类递质含量．结果：ＴＳ注入侧脑室后，血压由１１５９±０８４升至１４５９±０６９ｋＰａ，心率由４１１±２１增至４６５±１４次／分；外周血中ＮＥ，Ｅ的含量分别由６±３和６±２升至６４±４４和３８±３４ｎｍｏｌ／Ｌ血浆；脑干内的ＮＥ由３３±７升至４５±８ｎｍｏｌ／ｇ湿组织；端脑、间脑及脑干内的５ＨＴ分别由９±１，１４±２及１４±３降至５±１，７±２和６±１ｎｍｏｌ／ｇ湿组织．结论：中枢内的ＴＳ的心血管效应与单胺类递质有关．AIM: To study the cardiovascular effect of total soyabeans saponins (TS) in brain and its relation￣ship with monoamines. METHODS: After injection of TS (75 μg) into ventriculus lateralis cerebri (VLC) the changes of blood pressure (BP) and heart rate (HR) were observed and the contents of monoamines both in peripheral blood and brain (telencephalon, diencephalon, brain￣stem) were measured respectively by HPLC ECD and fluoro￣photometry. RESULTS: After injection of TS into VLC, BP rised from 11 59±0 84 to 14 59±0 69 kPa; HR increased from 411±21 to 465±14 bpm; the contents of NE and E in peripheral blood increased from 6±3 to 64± 44, from 6±2 to 38±34 nmol/L plasma, respec￣tively, NE in brainstem increased from 14±0 to 18±3 nmol/g wet tissue respectively, but the contents of 5 HT in the 3 areas measured in the experiment decreased: in telecephalon from 9±1 to 5±1, in diencephalon from 14±2 to 7±2, in brainstem from 14±3 to 6±1 nmol/g wet tissue. CONCLU￣SIONS: The cardiovascular effects of TS in CNS were involved in the monoamine transmitters.

关 键 词：大豆类 皂苷类 血压 心率 脑 生物单胺类 

分 类 号：R285.5[医药卫生—中药学] R282.710.5[医药卫生—中医学]