M_1，M_2受体激动剂和阻滞剂对犬呼吸的影响  

Effects of M 1 and M 2 receptor agonists and blockers on dog respiration 1

作　　者：姚兵[1] 葛晓群[1] 郑加林[1] 秦伟[1] 卞春甫[1] 

机构地区：[1]徐州医学院药理教研室

出　　处：《中国药理学报》1996年第3期267-270,共4页Acta Pharmacologica Sinica

摘　　要：目的：研究Ｍ１和Ｍ２受体激动剂和阻滞剂对犬呼吸的影响．方法：用ＲＭ８６多导生理记录仪通过胸带式呼吸换能器测定ＲＲ，ＴＶ和ＭＶＶ，并取动脉血测ｐＯ２，ｐＣＯ２和ｐＨ．结果：发现Ｍ１Ｒ激动剂Ｐｉｌ和Ｍ２Ｒ激动剂６βＡＮｉｖ或椎动脉给药分别产生呼吸兴奋和抑制，ＲＲ，ＭＶＶ增高或降低（Ｐ＜００５），血气亦出现相应变化．Ｍ１Ｒ阻滞剂Ｐｉｒ，Ｓｃｏ和Ｍ２Ｒ阻滞剂ＡＦＤＸ１１６，Ａｔｒ分别拮抗甚至翻转Ｐｉｌ的呼吸兴奋和６βＡＮ的呼吸抑制作用．结论：激动呼吸中枢Ｍ１Ｒ呼吸兴奋，激动呼吸中枢Ｍ２Ｒ呼吸抑制，阻断之则作用相反．IM: To study the effects of M 1 and M 2 receptor agonists and blockers on dog respiration. METHODS: Using thoracic respiratory transducer and RM 86 multipurpose polygraph to determine respiratory rate (RR), tidal volume (TV), and minute ventilation volume (MVV), and DH 100G blood gas analysis instrument to analyze p O 2, p CO 2 and pH. RESULTS: Pilocarpine (Pil, an M 1 R subtype agonist) 0 5, 1, and 2 mg·kg -1 iv caused increases in RR, MVV, and p O 2, and a decrease in p CO 2. The excitatory effects of Pil were antagonized by pretreatment with pirenzepine (Pir, 3 mg·kg -1 , iv) and scopol ￣amine (Sco, 2 mg·kg -1 , iv). The iv injections of a novel M 2 R subtype agonist, 6β acetoxy nortropane (6β AN) 2, 5, and 20 μg·kg -1 caused decreases in RR, MVV, and p O 2 and an increase of p CO 2. The actions of 6β AN were antagonized by iv pretreatment with AF DX116 {11 2[[2 [(diethylamino)methyl] 1 piperidinyl]acetyl] 5,11 dihydro 6Hbenzodiazepine 6 one, 0 5 mg·kg -1 } and atropine (Atr, 2 mg·kg -1 ). Similar results were obtained when smaller doses of Pil (0 2, 0 4, and 0 8 mg·kg -1 ) and 6β AN (0 25, 0 5, and 1 μg·kg -1 ) were injected into the vertebral artery. Pir and Sco also antagonized the excitatory effects of Pil, and AF DX116 and Atr antagonized the inhibitory effects of 6β AN on respiration. CONCLUSION: Stimulating M 1 R of the respiratory center caused excitation of the respiration while stimulating the M 2 R subtype caused inhibition of the respiration.

关 键 词：毒蕈碱 受体 匹鲁卡品 去甲托烷类 呼吸 

分 类 号：R965.1[医药卫生—药理学] R966[医药卫生—药学]