氯化血红素抗贫血疗效和毒性  

Effect of hemin in treating hemorrhagic anemia and toxicity

作　　者：游开绍[1,2,3] 吴斌[1,2,3] 黄自强[1,2,3] 张柽[1,2,3] 潘林金[1,2,3] 吴国土[1,2,3] 赵子庆[1,2,3] 黄妙辉[1,2,3] 

机构地区：[1]福建医学院附属第一医院 [2]福建医学院药理学教研室 [3]福建省医学科学研究所生化研究室

出　　处：《中国药理学报》1996年第3期284-286,共3页Acta Pharmacologica Sinica

摘　　要：目的：探讨氯化血红素（ｈｅｍｉｎ）治疗贫血的疗效及其口服的毒性反应．方法：用自制的ｈｅｍｉｎ按每日９３，１６８，３００ｍｇ·ｋｇ－１治疗失血性贫血大鼠，并与葡萄糖酸亚铁（ＦＧ３００ｍｇ·ｋｇ－１·ｄ－１）治疗组及单纯给水组比较．２４ｈ内对２０只小鼠予ｈｅｍｉｎ６ｇ·ｋｇ－１灌胃以观察小鼠的急性毒性反应．对８０只大鼠连续３个月分别予ｈｅｍｉｎ０６５，１３，２６ｇ·ｋｇ－１·ｄ－１灌胃，观察大鼠的长期毒性反应．结果：治疗后各组Ｈｂ变化依次为６６→１２１，７１→１４１，６６→１４８，６９→１４１，６７→１１２ｇ·Ｌ－１；观察７ｄ未见小鼠急性毒性反应；用药３个月后对８０只大鼠进行血象检查、肝肾功能检查及１５个脏器组织活检均未见明显异常．结论：Ｈｅｍｉｎ抗贫血疗效优于ＦＧ；口服无任何毒副作用．IM: To study the effect of hemin in treating hemorrhagic anemia and toxicity. METHODS: Fifty rats with hemorrhagic anemia were randomly divided into 5 groups with different dosage of hemin (93, 168, 300 mg·kg -1 ·d -1 ), ferrous gluconate (FG 300 mg·kg -1 ·d -1 ), and water, ig for 7 d. Twenty mice fed with hemin (6 0 g·kg -1 ·d -1 ) in 24 h for observing acute toxicity effects. Long term toxicity were observed in 80 rats given hemin (0 65, 1 3, 2 6 g·kg -1 ·d -1 ) in 3 months. RESULTS: Hb of the rats of corresponding groups were 66→121, 71→141, 66→148, 69→ 140, and 67→112 g·L -1 . There were no adverse effects observed on acute toxicity test. No abnormalitis were found in hemogram, liver renal function test, and autopsy. CONCLUSION: Hemin had a better effect than FG and no adverse effect was found in hemin.

关 键 词：氯化血红素 低色素性 贫血 毒理学 

分 类 号：R965.3[医药卫生—药理学] R994.1[医药卫生—药学]