新农药叶枯灵的毒性研究  

STUDIES ON THE TOXICITY OF A NEW FUNGICIDE "YE KU LING"

作　　者：孙棉龄[1] 朱振华[1] 曾祥贵[1] 衡正昌[1] 张遵真[1] 

机构地区：[1]华西医科大学公共卫生学院环境卫生学教研室

出　　处：《重庆环境科学》1989年第6期11-15,共5页Chongqing Environmental Science

摘　　要：农药叶枯灵是我国新研制的一种有机硫杀菌剂.本研究对其中试产品(原药)进行了经口急性毒性、蓄积性毒性、致突变性、致癌性与致畸性试验.结果表明:对大、小鼠的LD_(50)分别为132和109mg/kg,属中等毒性;在大鼠体内无明显蓄积作用;Ames试验、枯草杆菌重组试验、小鼠微核试验,体外SHE细胞转化试验均为阴性,无遗传毒性和致畸作用.'Ye Ku Ling' (2-benzoyl-hydrazono-1, 3-dithiolane) is a new organosulfur fungicide developed and made by Chongqing Pesticide Factory. It is quite effective in control of bacterial blight of rice. This paper reports the experimental studies on the toxicity of its technical product. The results of the studies show that the LD_(50) for rats and mice are equal to 132 and 109 mg/kg respectively. There is no significant cumulative effect in rats. The results of Ames test, rec assay of B. subtilis, micronucleus test in mice and the SHE cell transformation assay are all negative. No genotoxic and teratogenic effects are observed.

关 键 词：农药 有机硫 毒性 杀菌剂 叶枯灵 

分 类 号：S482.22[农业科学—农药学]