云母对实验性胃溃疡愈合质量的影响  

The effect of muscovite on the quality of gastric ulcer healing

作　　者：姒健敏[1] 钱云[1] 吴加国[1] 

机构地区：[1]浙江大学邵逸夫临床医学研究所,浙江杭州310016

出　　处：《中国中药杂志》2005年第19期1536-1541,共6页China Journal of Chinese Materia Medica

基　　金：浙江省科技厅一般项目(011103018)

摘　　要：目的:探讨云母对实验性胃溃疡愈合质量的影响。方法:建立实验性醋酸致大鼠胃溃疡模型,成模后分组给药治疗14 d,取其标本,评估再生黏膜组织学及功能成熟度,以判定溃疡愈合质量。结果:经云母治疗后,大鼠再生黏膜厚度增加、囊状扩张腺体数目减少,肉芽组织炎症细胞浸润数量减少、微血管数量增加、胶原面积增加,黏膜中性黏液和氨基己糖分泌增多,血浆PGE2,EGF分泌增多,免疫组化染色中黏膜局部EGFR,bFGF阳性细胞表达增强。结论:云母能提高再生黏膜组织学及功能成熟度,最终达到高质量的溃疡愈合。Objective： To explore the effect of muscovite on the quality of gastric ulcer healing. Method： Gastric ulcers were produced in male rats by serosal application of acetic acid. Rats were gavaged for 14 days with saline, omeprazole and muscovite starting 3 days after ulcer induction. Then the tissue and blood samples were obtained and measured. Result： In the muscovite group, restored mucosa thickness increased, cystically dilated glands decreased, microvessels in connective tissue increased, the secretion of mucus, hexosamine, PGE2, EGF, bFGF were enhanced, and the express of EGFR was stronger. Conclusion： Muscovite can promote the gastric ulcer healing and improve the quality of gastric ulcer healing.

关 键 词：云母 胃溃疡 溃疡愈合质量 

分 类 号：R285.5[医药卫生—中药学]