膳食低钙在克山病心肌坏死发生中的作用——离体大鼠心脏低钙和低氧灌流对心肌损伤的实验研究  

EFFECTS OF LOW CALCIUM DIET ON PATHOGENESIS OF MYOCARDIAL NECROSIS OF KESHAN DISEASE:THE STUDY OF HYPOCALCIUM AND HY-POXIA ON THE MYOCARDIAL INJURY IN PERFUSED RAT HEARTS

作　　者：郭成浩[1] 康德仁[2] 李广生[2] 王凡[2] 

机构地区：[1]青岛大学医学院 [2]白求恩医科大学地方病研究所

出　　处：《中国地方病防治》1996年第5期258-259,共2页Chinese Journal of Control of Endemic Diseases

基　　金："八五"项目

摘　　要：为说明膳食低钙在克山病心肌坏死发生中的作用,本文用Langendorff法灌流Wistar大鼠心脏。当灌流液中游离钙(free Ca^(2+))由1.0mmol/L降低至0.8、0.6、0.4、0.2mmol/L时,流出液中CK量增加。当用低钙0.4、0.5、0.6mmol/L先灌注10min后,再给予低氧15min,流出液中CK量明显高于1.0mmol/L的对照组。结果表明,低钙合并低氧造成灌流心肌损伤严重。To study that low calcium diet plays an important role in the pathogenesis of myocardial necrosis in Keshan disease, when free-Ca2+decreased from 1. 0 mmol/L to 0. 8,0. 6,0. 5, 0. 2 mmol/L of perfusion solution in the model of Langendorff apparatus perfused rat hearts, CK of effluent increased. After hypocalcium 10 minute,hypoxia 15 minute make CK of effluent higher than that of 1. 0mmol/L group. The results declare that hypocalcium combined hypoxia make myocardial injury severely.

关 键 词：低钙 低氧 心肌损伤 克山病 膳食 

分 类 号：R542.302[医药卫生—心血管疾病] R151.4[医药卫生—内科学]