基于纳米脂质体的马卡制剂的制备及其性质研究  

Study on the Preparation and Properties of Maca Pharmaceutics Based on Lipid Nanoparticles

作　　者：王柯敏[1,2,3,4] 郑明彬[1,2,3,4] 吴萍[1,2,3,4] 何晓晓[1,2,3,4] 林霞[1,2,3,4] 龚萍[1,2,3,4] 陈小洪[1,2,3,4] 

机构地区：[1]湖南大学化学生物传感与计量学国家重点实验室 [2]湖南省生物纳米技术工程中心 [3]湖南大学生物医学工程中心 [4]湖南大学化学化工学院,湖南长沙410082

出　　处：《湖南大学学报（自然科学版）》2005年第5期75-78,共4页Journal of Hunan University:Natural Sciences

基　　金：国家自然科学基金资助项目(20135010)国家重点基础研究发展规划资助项目(2002CB513100-10)国家科技攻关计划资助项目(2003BA310A16)国家科技发展规划资助项目(2003AA302250)科技部国际合作重点资助项目(2003DF000039)国家自然科学基金资助项目(20405005)

摘　　要：以大豆磷脂为载体,以葡萄糖液作为分散介质,采用旋转薄膜蒸发法,发展了一种新的马卡纳米制剂制备方法.考察了该方法制备的不同药脂比的马卡纳米制剂的粒径及其Zeta 电位,并对马卡的包封率、制备的马卡纳米制剂的胶体溶液物理稳定性以及冻干粉剂有关性质进行了研究.结果表明,不同药脂比的马卡制剂的平均粒径在100-150 nm之间,Zeta电位均小于-30 mV;通过该方法获得的马卡纳米制剂的包封率高,其胶体溶液具有很好的物理稳定性,30 d内,其粒径未发生显著变化,而且冻干粉剂的水再分散性较好.Maca nano-pharmaceutics was prepared by the rotary-film evaporation method with soya lecithin as the carrier and glucose solution as the dispersion medium. The particle size and Zeta potential of the maca nano-pharmaceutics with different maca/liposome weight ratio were studied. The entrapment efficiency and physiccal stability of the maca nano-pharmaceutics were investigated. The properties of freeze-dried maca nano- pharmaceutics were also studied. The results showed that the mean size of the maca nano-pharmaceutics was 100 -150 nm, and the Zeta potential was less than -30 mV. This maca pharmaceutics had high entrapment efficiency and physical stability of their colloidal solution was satisfactory; and freeze-dried maca nano-pharmaceutics could be resuspended easily in water.

关 键 词：马卡 纳米颗粒 制剂 

分 类 号：R944.1[医药卫生—药剂学]