甘草酸苷与乙型肝炎病毒复制关系的体外研究  

Study on the Relation of Glycyrrhizic Glycoside on Hepatitis B Virus Replication in Vitro

作　　者：蔺小红[1] 席宏丽[1] 徐小元[1] 傅希贤[1] 

机构地区：[1]北京大学第一医院,北京市100034

出　　处：《中国药房》2005年第20期1541-1543,共3页China Pharmacy

摘　　要：目的:研究甘草酸苷在体外试验条件下与乙型肝炎病毒复制的关系。方法:以2·2·15细胞株为试验对象,定量检测加入不同浓度甘草酸苷处理后细胞培养上清液中HBsAg、HBeAg的含量。结果:甘草酸苷浓度分别为800、400、200、100、50μg/ml时,对HBsAg抑制率依次为83·8%、71·0%、62·1%、52·0%、29·7%,表明其可抑制2·2·15细胞分泌HBsAg。结论:甘草酸苷在体外试验中未引起HBV复制活跃。OBJECTIVE： To study the relation of glycyrrhizic glycoside on hepatitis B virus （HBV） replication in vitro. METHODS： 2.2.15 cell line was used and treated with glycyrrhizic glycoside, the contents of HBsAg and HBeAg in the supernatant of cell culture with different concentrations of glycyrrhizic glycoside were quantified. RESULTS： The inhibitory rates of glycyrrhizic glycoside on HBsAg were 83.8%, 71.0%, 62.1%, 52.0% and 29.7% respectively at the concentrations of 800,400,200,100 and 50μg/ml respectively. CONCLUSION ：Glycyrrhizic glycoside does not promote HBV replication in vitro experiment.

关 键 词：复方甘草酸苷 甘草酸苷 乙型肝炎病毒 2.2.15细胞 

分 类 号：R965[医药卫生—药理学]