正交设计优选保肾颗粒剂喷雾制粒工艺  

Orthogonal experiments to select spraying granulation technique for Baoshen granules

作　　者：曲彩红[1] 杨莉[2] 黄际薇[1] 郑琼良[1] 

机构地区：[1]中山大学附属第三医院,广东广州510630 [2]南方医科大学附属南方医院,广东广州510515

出　　处：《中国中药杂志》2005年第20期1587-1588,共2页China Journal of Chinese Materia Medica

摘　　要：目的:为提高喷雾制粒颗粒的成品率及提高经济效益,需要筛选制备工艺.方法:采用新型喷雾制粒机制粒,以浸膏的提取工艺、黏合剂的用量、进出口的风温及辅料的配比为考察因素,每个因素2个水平,以颗粒的成品率为考察指标,采用正交试验设计法优选出最佳喷雾制粒工艺.结果:4因素中以黏合剂的用量影响最为明显,其次为进出口风的温度.浸膏的提取工艺及辅料的配比影响不大.结论:保肾颗粒剂最佳的喷雾制粒工艺条件为蔗糖与环糊精的配比为2:1;进风口的温度为90～100℃;出风口的温度为50～60℃;黏合剂的用量为O.5%.提取液以不经过醇沉为佳.Objective： To raise the end-product and economical efficiency of spraying granulation, we demand screening preparation technique. Method：Adopting newly spraying granulation technique, taking extracting technique, adhesive material, temperature of exit and entry, and the matching of accessories as inspecting factors, two levels of each factors, end-product as inspecting marker, we selected the best Baoshen granules preparation technique by orthogonal design. Result： Among the 4 factors, adhesive material is most notable, next is temperature of exit and entry, the other two is of little importance ,Conclusion optimum spraying granulation technique of Baoshen granules is A2B1C2D1.

关 键 词：喷雾制粒 颗粒剂 制备工艺 正交实验 

分 类 号：TQ461[化学工程—制药化工]