乳腺浸润性导管癌VEGF、COX-2和ER、PR的表达及意义  

The Expression of COX-2,VEGF,ER,and PR in Breast Cancer and their Significance

作　　者：刘兰芳[1] 李青山[1] 金晓平[1] 赵晓明[1] 

机构地区：[1]承德医学院附属医院肿瘤内科,承德067000

出　　处：《陕西医学杂志》2005年第11期1350-1352,共3页Shaanxi Medical Journal

摘　　要：目的:探讨血管内皮生长因子(VEGF)、环氧化酶-2(COX-2)和雌、孕激素受体(ER、PR)在乳腺浸润性导管癌中的表达及临床意义。方法:检测100例乳腺浸润性导管癌和40例良性乳腺肿瘤组织中COX-2、VEGF、ER、PR的表达情况,并分析它们与生物学行为的关系。结果:乳腺癌组COX-2阳性率达54%与对照组比较差异有统计学意义;VEGF阳性率为66%,与对照组比较差异有显著性。在ER、PR阴性组中,VEGF、COX-2阳性表达率较高。结论:COX-2、VEGF在乳腺浸润性导管癌组织中的高表达,与乳腺癌的生长、转移有密切关系,可以作为反映乳腺癌生物学行为和判断预后的有效指标。Objective： To investigate the expression of vascular endothelial growth factor （VEGF） , cyclooxygenase-2 （COX-2） and estrogen receptor （ER） and progesterone receptor （PR） in invasive ductal carcinoma （ IDC ） of breast and significant. Methods： The method of SP immuneohischemical technique was used to test the expression of COX-2 , VEGF, ER, PR in 100 breast cancer and 40 benign breast lesions. Results ： The ratio of positive expression of COX-2 is 54%, having significantly higher than that of.the control group. The ratio of positive expression of VEGF is 66%, showing significant difference with that of the control group. The expression of COX-2 , and VEGF has negative correlation compared with that of ER and PR. Conclusion： There was intimate relation between over-expression of VEGF and COX-2 in IDC of breast and metastasis, and they could act as the quota in deciding breast cancer prognosis and curative rate.

关 键 词：乳腺肿瘤/病理学 血管生长因子/分析 环氧化合物/分析 雌激素类 孕激素类 血管内皮生长因子(VEGF) 环氧化酶-2(COX-2) 乳腺浸润性导管癌 ER PR 

分 类 号：R446.61[医药卫生—诊断学] R735.2[医药卫生—临床医学]