甲状腺疾病中金属硫蛋白的表达检测及生物学意义  

The expression and biological significance of methallothionein in thyroid diseases

作　　者：陈林兴[1] 陈慎仁[1] 陈泽钦[1] 吴俊伟[1] 黄华[1] 

机构地区：[1]汕头大学医学院第二附属医院中心实验室,广东省515041

出　　处：《中华检验医学杂志》2005年第9期936-937,共2页Chinese Journal of Laboratory Medicine

基　　金：汕头市重大科技计划基金资助项目(200313)

摘　　要：目的探讨金属硫蛋白(MT)在不同甲状腺疾病中表达的检测及其生物学意义。方法应用免疫组织化学方法检测50例不同甲状腺疾病病理组织上MT的表达并比较其差别。结果MT在甲瘤、甲癌、Graves病和桥本甲状腺炎表达的阳性频度均为100%,甲癌中MT的AGV为87.60±9.20,明显高于甲瘤(62.20±12.40)、Graves病(61.10±13.20)和桥本甲状腺炎(58.50±10.60),P<0.05。结论MT与甲癌的发生发展关系密切,当AGA在80以上时,应高度警惕甲癌的可能。Objective To research the expression and biological significance of methallothionein （MT） in different thyroid diseases （TDs）. Methods The expression of MT was observed by immunohistochemical stain and the difference among TDs was compared. Results MT was completely expressed in all TDs. Expression of MT was 87. 60 ±9. 20 in thyroid carcinoma,significantly higher than that （62. 20± 12. 40） in thyroid adenoma, that（61.10±13.20） in Graves＇ disease and that（58. 50± 10. 60） in Hashimoto’ thyroiditis （ P 〈 0. 05 ）. Conclusion MT is closely related to thyroid malignancy, it maybe thyroid carcinoma if MT expression in thyroid tissue is higher than 80.

关 键 词：金属硫蛋白 甲状腺肿瘤 甲状腺疾病 生物学意义 表达检测 Graves病 免疫组织化学方法 桥本甲状腺炎 病理组织 发生发展 

分 类 号：R581[医药卫生—内分泌] R338[医药卫生—内科学]