阻塞性睡眠呼吸暂停低通气综合征患者手术治疗前后血管活性物质的变化  

The changes of some vasoactive substances after operation in patients with obstructive sleep apnea-hypopnea syndrome

作　　者：姚行齐[1] 孙艺[1] 褚勇[1] 罗燕云[1] 张桂凤[1] 王伦[2] 

机构地区：[1]广州军区武汉总医院耳鼻咽喉科,武汉430070 [2]湖北省军区门诊部

出　　处：《临床耳鼻咽喉科杂志》2005年第20期937-938,共2页Journal of Clinical Otorhinolaryngology

摘　　要：目的:观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者采用UPPP加舌骨悬吊术治疗前后血栓素B2(TXB2)、肾素、血管紧张素Ⅱ(AT-Ⅱ)、内皮素1(ET-1)和抗心磷脂抗体(ACA)的变化及手术对其的作用。方法:选择经PSG检查确诊的重度OSAHS患者54例,为OSAHS组,另设对照组20例,用酶联免疫吸附试验检测两组TXB2、肾素、AT-Ⅱ、ET-1及ACA,OSAHS组手术治疗后半年复查上述指标。结果:OSAHS组术前血浆TXB2、肾素、AT-Ⅱ、ET-1及ACA均高于对照组(P<0.05或P<0.01);OSAHS组手术治疗后半年上述指标均低于术前(P<0.05或P<0.01);TXB2、肾素、AT-Ⅱ、ET-1、ACA与AH I呈正相关,与SaO2呈负相关。结论:OSAHS患者易患血栓栓塞性疾病,并与夜间低氧血症密切相关,手术治疗可有效逆转上述改变。Objectie ： To observe the changes of thromboxane B2（TXB2）, rennin, angiotensin Ⅱ （ AT-Ⅱ）, endothelin 1（ET-1） and anticardiolipin antibody （ACA） in patients with obstructive sleep apnea hypopnea syndrome （OSAHS） before and after the operation. Method： Fifty-four cases of OSAHS confirmed by polysomnography （PSG） were selected as the OSAHS group and 20 normal donors without OSAHS were selected as the control group. Plasma levels of TXB2, rennin. AT-Ⅱ, ET-1 and ACA were detected by enzyme-linked immunosorbent assay （ELISA）.Result：Plasma levels of TXB2, rennin. AT-Ⅱ,ET-1 and ACA were higher in patients with OSAHS than those in control group（ P 〈0.05 or P〈0.01 ） .and the operation therapy decreased them significantly （ P〈0.05 or P〈0.01 ）. All the plasma parameters were correlated positively with AHI, and negatively with SaO2. Conclusion：The results indicate the patients with OSAHS were susceptible to thromboembolism disease. Operation therapy is effective in correcting TXB2. rennin, AT-Ⅱ ,ET-1 and ACA.

关 键 词：睡眠呼吸暂停低通气综合征 阻塞性 血栓素B2 血管紧张素Ⅱ 内皮素1 抗心磷脂抗体 外科 手术 

分 类 号：R563.8[医药卫生—呼吸系统]