尖锐湿疣组织中Bcl-2和Bax蛋白的检测和意义  

Detection and Significance of Bcl-2 and Bax Protein in Condyloma Acuminata

作　　者：尹光文[1] 赵卫华[1] 于建斌[1] 张云汉[2] 高冬玲[2] 傅世珍[1] 

机构地区：[1]郑州大学第一附属医院皮肤性病科,河南郑州450052 [2]郑州大学第一附属医院病理科

出　　处：《中国皮肤性病学杂志》2005年第10期586-587,共2页The Chinese Journal of Dermatovenereology

摘　　要：目的了解Bcl2和Bax蛋白在尖锐湿疣发病中的作用。方法用免疫组化SP法分别检测28例CA组织和14例正常上皮组织中Bcl2和Bax蛋白。结果Bcl2蛋白在28例CA组织中阳性率为46.43%,在14例正常上皮阳性率为14.29%,两者比较差异有显著性(P<0.01);28例CA组织中Bax蛋白阳性率75.00%,而14例正常上皮中阳性率57.14%,两组阳性率差异无显著性(P>0.05);Bcl2和Bax之间呈负相关(r=-0.611,P<0.05)。结论Bcl2和Bax可能与CA的发病有一定关系。Objective To detect Bcl-2 and Bax protein in keratinocytes of Condyloma acuminatum （ CA ）, and to explore their roles in pathogenesis. Methods Bcl-2 and Bax protein in 28 cases of CA and 14 normal controls were detected respectively by immunohistochemistry staining（SP）. Results Bcl-2 in CA were signitqcantly higher than those in normal samples（P 〈 0.01 ） , and there was a negative correlation between Bcl-2 and Bax （ r = - 0. 611, P 〈 0.05 ）. Conclusion Bcl-2 and Bax in CA may play some roles in CA pathogenesis.

关 键 词：BCL-2 BAX 尖锐湿疣 细胞凋亡 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]