鲑鱼降钙素(考克)治疗骨质疏松性骨痛的疗效评价  

Efficacy and safety of salmon calcitonin in the treatment of the pain with osteoporosis

作　　者：杜瑞琴[1] 詹志伟[1] 胡肇衡[2] 郑纪红[3] 唐小穗[4] 王丽[5] 扈文海[6] 张良[7] 

机构地区：[1]中国人民解放军第二炮兵总医院,北京100088 [2]北京大学人民医院,北京100044 [3]北京军区总医院,北京100700 [4]北京航天中心医院,北京100049 [5]天津医院,天津300211 [6]河北医科大学附属第三医院,石家庄050000 [7]卫生部北京医院,北京100730

出　　处：《中国新药杂志》2005年第10期1221-1224,共4页Chinese Journal of New Drugs

摘　　要：目的:评价鲑鱼降钙素(商品名考克)对骨质疏松性骨痛的疗效。方法:采用多中心自身对照研究,入选210例骨质疏松及骨量丢失伴有骨痛的患者,给予鲑鱼降钙素50 IU.d-1肌内注射,治疗2周,观察治疗前后骨质疏松性骨痛的变化。结果:199例患者完成治疗,自我评定及医生评分显示不同部位骨痛症状均消失或明显减轻,总有效率均在80%以上(P<0.005),其中无效者多为合并腰椎间盘突出等其他原因引起的疼痛。有31.43%(66/210)患者出现不良反应,多为恶心、脸红、头晕等,其中5.23%因反应严重或恐惧退出治疗。结论:鲑鱼降钙素治疗骨质疏松性骨痛快速、有效。Objective：To evaluate the efficacy and safety of salmon calcitonin in the treatment of the pain associated with osteoporosis. Methods： 210 patients with pain associated with osteoporosis or osteopenia were intramuscularly injected salmon calcitonin 50 IU daily for 2 weeks. The primary objective was to assess the pain relief. Results： 199 out of 210 completed the 4-week course of therapy. The pain assessment scales by patients and doctor all showed significant reductions of the pain relieves with an overall efficacy rate of 80 % or above （P 〈 0.05）. Patients who experienced the treatment failure were associated with concomitant diseases including protrusion of intervertebral disks. The incidence of adverse events was 31.43 %, including nausea, dizziness and blush. The incidence of serious adverse events was reported to be 5.23 %. Conclusion： Salmon calcitonin offers a therapeutic option in the treatment of the pain associated with osteoporosis.

关 键 词：鲑鱼降钙素 骨质疏松症 骨痛 疗效 

分 类 号：R969.4[医药卫生—药理学] Q57[医药卫生—药学]