老年人血瘀证对T淋巴细胞Ag-NORs及血液流变学的影响  

Changes of Ag-NORs of T Lymphocytes and Hemorheological Indexes in Old Patients with Blood Stasis Syndrome

作　　者：谢纪文 艾长征[1] 唐庆[1] 潘腊梅[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院中医科,武汉430022

出　　处：《中国中西医结合杂志》2005年第10期883-885,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：湖北省卫生厅科研基金资助项目(No.3-106)

摘　　要：目的观察老年人血瘀证对T淋巴细胞核仁形成区嗜银蛋白(Ag-NORs)及血液流变学指标的影响。方法选择54例老年血瘀证患者(血瘀证组),检测T淋巴细胞Ag-NORs及血液流变学指标,并与36例健康人(对照组)作对照观察。结果血瘀证组T淋巴细胞Ag-NORs含量(IS%)为5·857±0·396,对照组为6·111±0·541,两组比较,差异有显著性(P<0·05);血瘀证组多项血液流变学指标异常,与对照组比较,差异有显著性(P<0·05);老年血瘀证患者血液流变学检测值RVP、ESR、K1、K2与静脉血T淋巴细胞Ag-NORs含量呈负相关(r分别=-0·273、-0·335、-0·301、-0·276;P<0·01或P<0·05);聚集指数与静脉血T淋巴细胞Ag-NORs含量呈正相关(r=0·389,P<0·05)。结论T淋巴细胞Ag-NORs含量降低与多项血液流变学指标异常可能是老年血瘀证患者机体免疫功能下降的重要原因之一。Objective To observe the changes of Ag-NORs of T lymphocytes and hemorheological indexes in old patients with blood stasis （BS） syndrome. Methods Ag-NORs of T lymphocytes and hemorheological indexes in 54 old patients with blood stasis syndrome in the BS group were determined and compared with those in the control group consisted of 36 healthy persons. Results Contents of Ag-NORs of T lymphocytes in the BS group and the control group were 5.857 ＋ -0.396 and 6. 111 ± 0.541, respectively, showing significant difference （P〈0.05）. Some abnormal hemorheological indexes were seen in the BS group, which were significant different to those in the control group （P 〈 0.05）, Correlation analysis showed that RVP, ESR, K1 and K2 were negatively correlated with Ag-NORs of T lymphocytes （r = -0. 273, -0. 335, -0. 301, -0. 276 respectively;P〈0.01 or P 〈 0.05）, while aggregation index was positively correlated with Ag-NORs of T lymphocytes （r = 0. 389, P 〈 0.05）. Conclusion The lowered Ag-NORs of T lymphocytes and abnormal hemorrheological changes might be one of the important reasons for the lowered immunity of aged patients with BS syndrome.

关 键 词：老年人 血瘀证 T淋巴细胞核仁形成区嗜银蛋白 血液流变学 相关性 血液流变学指标 T淋巴细胞 NORS Ag 核仁形成区嗜银蛋白 

分 类 号：R255.7[医药卫生—中医内科学]