银杏叶提取物对早期糖尿病肾病的影响  

Effect of Extract of Ginkgo bilboa Leaf on Early Diabetic Nephropathy

作　　者：朱宏文 史正芳 陈云燕 钱秋芳 顾文勇[2] 

机构地区：[1]上海市嘉定区安亭医院内科,上海201805 [2]上海第二医科大学附属瑞金医院实验中心

出　　处：《中国中西医结合杂志》2005年第10期889-891,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的探讨银杏叶提取物(脑恩,extract of Ginkgo bilboa leaf,EGB)对早期糖尿病肾病(diabetic nephropathy,DN)的影响。方法将68例早期DN患者,分为对照组和治疗组。对照组给予常规治疗;治疗组在常规治疗的基础上加用EGB9·6mg,每天3次口服;两组均治疗3个月。比较两组治疗前后尿中微量白蛋白(microalbumin,mALB)、α1-微球蛋白(α-microglobulin,α1-MG)、免疫球蛋白G(IgG)、转铁蛋白(trans-ferrin,TF)、视黄醇结合蛋白(retinal binding protein,RBP)、N-乙酰-β-D-氨基葡萄糖苷酶(N-acety-beta-D-glu-cosaminidase,NAG)等检测指标。结果与治疗前比较,治疗组治疗后尿mALB、α1-MG、IgG、TF、RBP、NAG明显下降,差异有显著性(P<0·05),而对照组上述指标下降不明显(P>0.05)。结论EGB对早期糖尿病肾病具有保护作用。Objective To study the effect of extract of Ginkgo bilboa leaf （EGB） on renal lesions of early diabetic nephropathy （DN）. Methods Sixty-eight patients with early DN were randomly divided into two groups, the control group （34 patients） and the treated group （34 patients）. Patients in both groups received conventional therapy, while additional 9.6 mg EGB was orally taken by patients in the treated group, three times per day. The therapeutic course for both groups was three months. Indexes such as urinary microalbumin （mALB）,α1-microglobulin （α1-MG）, immunoglobulin （IgG）, transferrin （TF）, retinal binding protein （RBP） and N-acety-beta-D-glucosaminidase （NAG） before and after treatment between the two groups were compared respectively. Results Compared with before treatment, mALB, α1-MG, IgG, TF, RBP and NAG obviously decreased with significant difference in the treated group after treatment （P 〈 0.05）. However, no significant decrease in the above-mentioned indexes in the control group （P 〉0.05）. Conclusion EGB has the protective action on early DN.

关 键 词：银杏叶提取物 糖尿病肾病 尿微量白蛋白 早期糖尿病肾病 N-乙酰-Β-D-氨基葡萄糖苷酶 EXTRACT Α1-微球蛋白 视黄醇结合蛋白 protein 常规治疗 

分 类 号：R259[医药卫生—中西医结合]