何首乌脑保护作用机理研究的进展  

Progress of Study on Brain Protective Effect and Mechanism of Polygonum multiflorum

作　　者：王巍[1] 王丹巧[1] 

机构地区：[1]中国中医研究院西苑医院老年医学研究所,北京100091

出　　处：《中国中西医结合杂志》2005年第10期955-959,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然基金资助课题(No.30371824)

摘　　要：本文就近10年何首乌及其提取物有效成分二苯乙烯苷(2,3,5,4’-四羟基二苯乙烯-β-D-葡萄糖苷)对脑保护作用的机理研究进行了综述。它们的主要作用如下:(1)钙通道拮抗剂的作用;(2)抗氧化剂的作用;(3)拟胆碱药和胆碱脂酶抑制剂的作用;(4)调节细胞凋亡;(5)延缓衰老。何首乌的脑保护作用机理是多靶点、多环节、多途径的。因此,何首乌在老年痴呆、帕金森氏病、血管性痴呆等老年神经系统疾病的防治中具有很高的应用价值。This paper reviews the brain protective effect and mechanism of Polygonum multiflorum （PM）, its extracts and active component, tetrahydroxystilbene-glucoside （2,3,5,4＇ - tetrahydroxystilbene-2-O-β-D-glucoside） published in recent decade. They have major effects as calcium channel antagonists, antioxidant, cholinomimetic drugs and cholinesterase inhibitors, as well as actions in regulating cell apoptosis and prolonging the ageing. The brain protective mechanism of PM is multi-target, multi-link and multi-way. Therefore, PM has great applicative value in prevention and treatment of senile neuropathies, such as Alzheimer＇s disease, Parkinson＇s disease and vascular dementia, etc.

关 键 词：学习记忆功能 脑保护作用 何首乌 二苯乙烯苷 机理研究 胆碱脂酶抑制剂 钙通道拮抗剂 神经系统疾病 老年痴呆 帕金森氏病 

分 类 号：R285[医药卫生—中药学]