磷钨杂多酸一步法催化合成芳香基脂肪酸(英文)  

One-Step Catalytic Synthesis of Arylalkanoic Acids over 12-Tungstophosphoric Acid

作　　者：徐羽展[1] 毛建新[1] 郑小明[1] 

机构地区：[1]浙江大学催化研究所,浙江杭州310028

出　　处：《催化学报》2005年第10期835-836,共2页

基　　金：SupportedbytheScientificResearchFoundationfortheReturnedOverseasChineseScholars,StateEducationMinistry

摘　　要：首次提出用杂多酸为催化剂,利用芳烃及其衍生物和不饱和酸的傅-克烷基化反应一步合成相应的芳基脂肪酸,缩短了合成路线,同时避免了以往非绿色化的AlCl3催化合成.Arylalkanoic acids are key synthetic intermediates in the preparation of many natural products and synthetic drugs. For example, phenylacetic acid and its derivatives are valuable intermediates in the manufacture of pharmaceuticals, cosmetics and fragrances. Arylpropionic acid and its derivatives such as naproxen and ibuprofen have been applied in pharmaceutical treatments as anti-inflammatory and antifebrile medicines. Traditionally,

关 键 词：磷钨杂多酸 不饱和酸 烷基化 芳香基脂肪酸 

分 类 号：O625.54[理学—有机化学] O643.32[理学—化学]