基于体素的MRI形态分析诊断Alzheimer病的价值  

A voxel-based MRI morphometsic study of Alzheimer′s disease

作　　者：郝晶[1] 李坤成[1] 李可[2] 杨延辉[1] 王葳[1] 闫镔[2] 单宝慈[2] 

机构地区：[1]首都医科大学宣武医院医学影像学部 [2]中国科学院高能物理研究所核分析开放实验室

出　　处：《中华放射学杂志》2005年第10期1028-1033,共6页Chinese Journal of Radiology

摘　　要：目的评价基于体素的MRI形态分析(voxel-based Morphometry,VBM)法诊断Alzheimer病(AD)的价值。方法采用Siemens Sonata1.5T超导MR成像系统,对19例可能AD患者和15例年龄、性别与之相匹配的健康老年人及15例正常年轻人行全脑扫描,应用磁化准备快速梯度回波成像序列获取三维结构图像。数据分析采用以SPM99软件包为基础的全自动VBM技术进行处理。结果与健康老年对照组比较,AD患者两侧内颞叶(海马)明显萎缩(P<0.001),右侧海马减少的体素总数为1529个,左侧海马减少的体素总数为1281个;而且AD患者右侧尾状核头和左侧内侧丘脑亦明显萎缩,减少的体素总数均为1529个;而感觉运动皮层、枕叶及小脑相对保持完好。此外,AD患者大脑皮层萎缩具有不对称性。结论VBM法操作简单,可自动化观察AD全脑萎缩情况,所得结论不仅与既往神经影像学研究结果一致,并得到了有重要价值的新发现,具有广阔的临床应用前景。Objective To assess the diagnostic value of voxel-based Morphometry （VBM） in studying Alzheimer＇s disease（AD）. Methods Gray matter density were comprehensive assessed by means of VBM on T1-weighted MRI volume sets in 19 patients with AD and 15 healthy subjects of similar age and gender ratio, 15 healthy adults. The data were collected on Siemens 1.5 T Sonata MRI systems and analyzed by SPM 99 to generate gray matter density map. Results Relative to healthy controls, significant clusters of reduced gray matter density were found to affect medial temporal lobe （hippocampus） （P 〈 0. 001 ）. For hippocampus, reduced gray matter density were 1529 in the right and 1281 in the left with right-sided predominance. Moreover, atrophy of right caudate head and left medial thalamus were showed. We demonstrate global asymmetrical cortical atrophy with sparing of the sensorimotor cortex, occipital lobe and cerebellum. Conclusion The results from VBM are in perfect agreement with those of earlier neuroimaging, which confirmed its value in demonstrating neuroanatomy of AD. VBM, the simple and automatic approach providing a full-brain assessment of AD morphology, has a good clinical perspective.

关 键 词：阿尔茨海默病 磁共振成像 图像处理 计算机辅助 诊断 ALZHEIMER病 形态分析 MRI 体素 价值 健康老年人 

分 类 号：R445.2[医药卫生—影像医学与核医学]