不同对比剂注射流率下多层螺旋CT肝脏灌注值的比较  

Effect of different injection rates of contrast medium on hepatic perfusion by using multi-slice spiral CT

作　　者：史丽静[1] 田建明[1] 毕永民[2] 田军[1] 李树平[1] 陈炜[1] 王敏杰[1] 

机构地区：[1]上海第二军医大学附属长海医院放射科,200433 [2]北京空军总医院核磁共振科

出　　处：《中华放射学杂志》2005年第10期1060-1063,共4页Chinese Journal of Radiology

摘　　要：目的探讨使用不同对比剂注射流率对测定肝脏CT灌注值的影响。方法60例健康志愿者分成3组,每组20例,分别使用4、5、7ml/s的注射流率进行多层螺旋CT肝脏灌注测量,比较各组间灌注值。结果4和5ml/s组、5和7ml/s组,各项指标差异均无统计学意义(P>0.05);而4和7ml/s组间,4ml/s组的肝动脉灌流量(HAP)、门静脉灌流量(HPP)和肝脏总灌流量(TLP)值都明显高于7ml/s组HAP(0.37±0.16)ml.min-1.ml-1与(0.26±0.10)ml.min-1.ml-1,t=0.105,P=0.010;HPP(0.68±0.19)ml.min-1.ml-1与(0.51±0.13)ml.min-1.ml-1,t=0.172,P=0.001;TLP(1.05±0.30)ml.min-1.ml-1与(0.77±0.18)ml.min-1.ml-1,t=0.277,P=0.001。结论肝脏CT灌注测量,不同对比剂注射流率可影响灌注指标的测定,高流率的测定结果数值<较低的流率。实际应用中,要权衡灌注效果及安全性,采用5ml/s的流率即可得到满意结果。Objective To access the effect of different injection rates of contrast medium on hepatic perfusion by using multi-slice spiral CT （MSCT）. Methods Sixty volunteers underwent liver dynamic CT scan, they were divided into three groups according to different injection rate of contrast medium （4 ml/s, 5 ml/s, and 7 ml/s, respectively）. Their hepatic perfusion parameters were calculated and the results were compared between the three groups. Results There are five perfusion data： hepatic arterial perfusion （HAP）, hepatic portal perfusion （HPP）, total liver perfusion （TLP）, hepatic arterial perfusion index （HPI）, hepatic portal perfusion index （PPI）. There is no significant difference of all indexes when compared 4 ml/s to 5 ml/s group, and 5 ml/s to 7 ml/s group, whereas HAP, HPP and TLP of 4 ml/s group were significant higher than those of 7 ml/s group. HAP： （0. 37 ±0. 16） ml · min^-1· ml^-1 vs （0. 26 ± 0.10） ml· min^-1· ml^-1, t=0.105, P=0.010; HPP： （0.68 ±0.19） ml · min^-1· ml^-1 vs （0.51 ± 0.13） ml·min^-1 · ml^-1, t=0.172, P=0.001; TLP： （1.05 ±0.30） ml · min^-1· ml^-1 vs （0.77± 0. 18 ） ml · min^-1 · ml ^-1, t = 0. 277, P = 0. 001. Conclusion When evaluate liver perfusion with MSCT, the higher the injection rate of contrast medium, the lower the perfusion data. In clinical practice, perfusion effect, security and condition of patient should thought over to select a proper injection rate, To this study, 5 ml/s is enough.

关 键 词：肝 灌注 局部 体层摄影术 X线计算机 造影剂 多层螺旋CT 肝脏灌注 注射流率 对比剂 测定结果 CT灌注 

分 类 号：R816.5[医药卫生—放射医学]