超声定量分析脂肪肝图像与肝功能的关系  

The Relationship Between Quantitative Analysis with Ultrasonography and Liver Function in Fatty Liver Diseases

作　　者：王立[1] 何苗苗[1] 周宇谦[1] 

机构地区：[1]复旦大学附属金山医院影像中心,上海200540

出　　处：《中国临床医学》2005年第5期904-907,共4页Chinese Journal of Clinical Medicine

摘　　要：目的：探讨肉眼观察超声显示脂肪肝衰减情况及定量测量肝灰阶值反映相对衰减程度与肝功能的关系。方法 超声检查90例 体检人群；所有检查保证超声调节条件一致；肉眼观察肝脏图像按衰减程度分正常组，轻度脂肪肝，中度脂肪肝和重度脂肪肝；采图后 用 PHOTOSHOP 软件定制直方图取样范围，测量肝深层灰阶值(GSLD)、肝浅层灰阶值(GSLS)、右肾皮质灰阶值(GSK)，并计算肝脏 浅深层部灰阶比值(GSLS/GSLD)及肝浅层肾脏皮质灰阶比值(GSLS/GSK)反映相对衰减程度；抽血检查谷丙转氨酶(ALT)、门冬氨 酸转氨酶(AST)、γ-谷氨酰转肽酶(GGT)。结果 所有肉眼观察脂肪肝人群 ALT 高于正常组；中、重度脂肪肝 AST、GGT 高于正常 组。ALT、AST、GGT 与肉眼观察脂肪肝程度呈正相关。ALT、AST，GGT 阳性组 GSLS、GSK、GSLS/GSLD、GSLS/GS 较 ALT、AST， GGT 正常组有显著性差异。GSLS、GSLS/GSLD、GSLS/GSK 与脂肪肝程度呈正相关。多元回归分析显示，相对衰减程度 GSLS/ GSLD、GSLS/GS 与肝功能关系最大。结论 超声图像灰阶测量可用于定量评估脂肪肝。Objective： To investigate the relationship between liver function and the attenuation degree of visible assessment and quantitative analysis of gray scal on ultrasonography in patients with fatty liver diseases. Methods： The ultrasonography of liver and kidney was performed in 90 cases with the same condition. All cases divided into four groups according to visible attenuation assessment of liver image, namely, low fatty liver, median fatty liver, high fatty liver and normal cases. The gray scale values of surficial liver（GSLS）, deep liver （GSLD） and right kidney cortex （GSK） on ultrasonography were measured by histogram of Photoshop software. The levels of serum ALT, AST and GGT were measured respectively. Results： The value of ALT in all patients with fatty liver was significantly higher than that in the control. The AST and GGT in all patients with median and high fatty liver were significantly higher than those in the control. Positive correlation was found between different groups and serum ALT,AST and CGT. The GSLS in patients with fatty liver were significantly higher than those in the control group, The GSK in patients with fatty liver were significantly lower than those in the control group. The gray scale of surficial liver in groups with high level of ALT, AST and GGT were significantly higher than those in the normal group. Positive correlation was found between GSLS.GSLS/GSLD.GSLS/GSK and serum ALT, AST and GGT. Multinomial Regression procedure showed that GSLS/GSLD.GSLS/GSK were most correlated with liver function. Conclusion：The measurement of gray scale can quantitative assess fatty liver.

关 键 词：脂肪肝 超声 灰阶值 直方图 肝功能 

分 类 号：R445.1[医药卫生—影像医学与核医学]