氯诺昔康复合异丙酚静脉麻醉用于人流术的效果  

Effects of Lornoxicam Combed with Propofol for Anesthesia in Therapeutic Abortion

作　　者：邱爱军[1] 史永胜[1] 刘高望[1] 刘友刚[1] 

机构地区：[1]南方医科大学南方医院麻醉科疼痛诊疗中心,广州510515

出　　处：《中国临床医学》2005年第5期921-922,共2页Chinese Journal of Clinical Medicine

摘　　要：目的：评价氯诺昔康复合异丙酚静脉麻醉用于人流术的临床效果及安全性。方法：60例门诊行人流术的早孕妇，随机分为氯 诺昔康组(L 组，n=30) 和芬太尼组(F 组，n=30) ，静脉注射氯诺昔康16mg(L 组)、芬太尼1μg·kg^(-1) (F 组)后2min，两组均复合异丙 酚静脉麻醉。观察平均动脉压(MAP)、心率(HR)、脉搏氧饱和度(SpO_2) 、意识消失及恢复时间、离院时间、异丙酚总量及不良反应。 结果：用药后2min，两组 MAP、SpO_2均明显低于用药前(P＜0． 01) ；该时点 SpO_2 F 组明显低于 L 组(P＜0． 01) ；意识消失时间 F 组早 于 L 组(P=0． 032) ；两组意识恢复时间(P=0． 427) 及异丙酚总量(P=0． 134) ，组间比较均无显著差异；离院时间 L 组明显早于 F 组 (P＜0． 01) 。清醒后眩晕 L 组明显少于 F 组(P＜0． 01) 。结论：氯诺昔康或芬太尼复合异丙酚静脉麻醉用于人流术镇痛效果相似，但 前者呼吸抑制等不良反应轻，有利于病人早期离院。Objective：To evaluate the clinical efficacy and safety of anesthesia with intravenous lomoxicam combined with propofol for therapeutic abortion. Methods： Sixty pregnant women thnearly stage（ASA Ⅰ-Ⅱ） were scheduled for therapeutic abortion. They were randomly assigned into two groups to receive anesthesia with either intravenous lornoxieam 16rag （group L ,n = 30） or fentanyl 1μg · kg^-1 （group F, n = 30）, and both groups were all combined with the treatment of propofol. The mean arterial blood pressure（MAP）, heart rate（HR）, oxygen saturation（SpO2）, consciousness loss time,recovery time and discharged from hospital time, dosage of propofol and adverse effects were recorded. Results： MAP and SpO2 were significant lower 2 min after anesthesia induction than before anesthesia induction（P〈0.01 ）, SpO2 was lower group F in than in group L（P〈0. 01 ）. Consciousness loss time was earlier than group L（P = 0.032）. There was no significant difference of consciousness recovery time between group L and F（P = 0. 427）, but discharged time of from hospital group L was earlier than that of group F（P〈0. 01 ）, and Giddiness after consciousness recovery of Group Lwas less than group F（P〈0. 01 ）. There was no significant difference in the dosage of propofol between two groups（P = 0. 134）. Conclusion： The effects of anesthesia with either intravenous lornoxicam or fentanyl combined with propofol for therapeutic abortion were similar, but the adverse effects of intravenous lonoxicam was less than fentanyl, which can help the patients discharged from hospital earlier.

关 键 词：氯诺昔康 芬太尼 异丙酚 麻醉静脉内 人工流产 

分 类 号：R713.41[医药卫生—妇产科学]