糖尿病性勃起功能障碍大鼠模型的建立  

Establishment of Diabetic Rats Models with Erectile Dysfunction

作　　者：陈卫国[1] 严春寅[1] 侯建全[1] 薛义军[1] 王恒兵[1] 

机构地区：[1]苏州大学附属第一医院泌尿外科,江苏苏州215006

出　　处：《苏州大学学报（医学版）》2005年第5期822-823,826,共3页Suzhou University Journal of Medical Science

摘　　要：目的建立糖尿病性勃起功能障碍大鼠模型。方法50只大鼠禁食18 h后腹腔内注射四氧嘧啶200mg/kg制造糖尿病动物模型。应用阿朴吗啡100μg/kg后观察正常组、药物对照组和糖尿病组大鼠的阴茎勃起情况。结果四氧嘧啶致糖尿病大鼠的第一次成模率为76%(38/50),第二次成模率为100%(4/4)。阿朴吗啡引起正常组和药物对照组大鼠的阴茎勃起率为100%,而糖尿病大鼠仅为38.1%(16/42),二者比较有显著性差异(P<0.05)。结论四氧嘧啶腹腔内注射能安全且有效地建立糖尿病模型;在糖尿病大鼠中应用阿朴吗啡可筛选出勃起功能障碍的动物模型。Objective To establish suitable diabetic rats models with erectile dysfunction. Methods Alloxan of 200 mg/kg were injected into abdominal cavities in 50 Sprague-Dawley rats after 18 hour＇s starvation; then penis erection was observed in the normal group, medicine group and diabetic group. Results Alloxan was able to induce diabetes in 76% （38/50） rats for the first time and in 100%（4/4） rats for the second time. The rate with penis erection in diabetic group was only 38% （16/42） which was much lower than that in the normal group and medicine control group（100 % ） by injecting apomorphine of 100 μg/kg （P 〈 0.05）. Conclusion Alloxan injected intraperitoneally can construct diabetic rats models safely and effectively. Apomorphine can be used to select erectile dysfunction rats models with diabetes.

关 键 词：糖尿病 勃起功能障碍 大鼠模型 

分 类 号：R587.1[医药卫生—内分泌]