生物活性复合材料在生物矿化过程中的微观形貌与离子浓度变化  

Changes of Micromorphology and Ion Concentrations for Bioactive Composite Materials During the Process of Biomineralization under Physiological Condition

作　　者：郑裕东[1] 王迎军[2] 杨槐[1] 陈晓峰[2] 陈中华[2] 吴刚[2] 谢建新[1] 

机构地区：[1]北京科技大学材料学学院,北京100083 [2]广州华南理工大学材料学院,广州510640

出　　处：《高等学校化学学报》2005年第11期2140-2144,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金重点项目(批准号:59932050);国家重点基础研究发展项目(批准号:2005CB623902);广东省重点科技攻关项目(批准号:A302020202)资助

摘　　要：采用3-羟基丁酸酯-3-羟基戊酸酯的共聚物(PHBV)与磷酸三钙(TCP)、羟基磷灰石(HA)、生物活性玻璃(BG)等进行复合,获得了性能优良的生物活性骨组织工程支架材料和骨修复材料.研究和比较了3种复合材料在体外模拟生理环境中发生的生物矿化反应,对比了反应前后因矿化物的形成导致的表面微观形貌的变化,通过检测反应液离子浓度的变化对不同材料的矿化过程和生物活性进行了定量表征.研究结果表明,3种复合材料在模拟生理溶液中发生生物矿化的过程和程度不同,其中PHBV/BG的生物活性反应最为明显.Three kinds of＇bone tissue engineering scaffolds and bone repaired materials with excellent properties were prepared by using poly （3-hydroxybutyrate-co-3-hydroxyvalerate） （PHBV） and bioactive glass （BG）,tricalcium phosphate（TCP）, hydroxyapatite （HA） compounds. The changes in surface micromorphology and ion concentration of reaction solution for the three kinds of composite materials were investigated and compared before and after soaking in simulated body fluid（SBF） solution. Results obtained in this work indicated that the biomineralization and ion exchange reaction and degradation occurred in PHBV/BG, PHBV/TCP and PHBV/HA composites in SBF solution, and mineralized layer formed on the surface of these composites which was proved as hydroxyl carbonate apatite （HCA）. But the processes and grade of biomineralization were distinct for PHBV/BG, PHBV/TCP and PHBV/HA composites, the bioactivity of PHBV/BG was better than others.

关 键 词：生物矿化 模拟生理溶液 生物活性 碳酸羟基磷灰石 

分 类 号：O631[理学—高分子化学]