α-甲硫基环十二酮肟醚的合成及杀菌活性  

Synthesis of α-Methylthiocyclododecanone Oxime Etherand Fungicide Activity

作　　者：宋彦楠[1] 王道全[1] 王明安[1] 

机构地区：[1]中国农业大学应用化学系,北京100094

出　　处：《农药学学报》2005年第3期210-214,共5页Chinese Journal of Pesticide Science

基　　金：国家重点基础研究发展计划(973计划)资助项目(No.2003CB114407)

摘　　要：以环十二酮为原料,经α-甲硫基环十二酮制得中间体α-甲硫基环十二酮肟后,经烷基(芳基)化反应合成了10个α-甲硫基环十二酮肟醚,其结构经元素分析1、H NMR1、3C NMR和IR的确证。初步生测结果表明,部分化合物对立枯丝核菌Rhizoctonia solani、褐孢霉菌Fulvia fulva(cooke)cifer、灰霉病菌Botrytis cinerea等病原菌具有较好的杀菌活性,其中F3和F8对立枯丝核菌的EC50值为11.22和13.38μg/mL,对褐孢霉菌的EC50值为37.12和48.41μg/mL,F9对灰霉病菌的EC50值为17.96μg/mL。Ten new α-methylthiocyclododecanone oxime ether were synthesized by the reaction of alkylation of α-methylthiocyclododecanone oxime as intermediate with alkyl halides, which were prepared from α-methylthiocyclododecanone oxime and cyclododecanone as starting material. Their structures were confirmed by elemental analysis, ^1H NMR, ^13C NMR and IR spectra. The preliminary bioassay results showed that some of compounds have good fungicidal activities against Rhizoctonia solani, Fulvia fulva （cooke） cifer and Botrytis cinerea. The EC50 values of F3 and F8 against R. solani and F. fulvia were 11.22 and 13.38μg/mL, 37.12 and 48.41μg/mL, and EC50 value of F9 against B. cinerea was 17.96μg/mL, respectively.

关 键 词：α-甲硫基环十二酮 α-甲硫基环十二酮肟醚 合成 杀菌活性 

分 类 号：Q754[生物学—分子生物学] S481.4[农业科学—农药学]