Design and Synthesis of Novel Fluorine-containing Acrylates  

作　　者：Yan Chao WU Chao WU Xiao Mao ZOU Fang Zhong HU Hua Zheng YANG 

机构地区：[1]State Key Laboratory of Element-Organic Chemistry, Institute of Element-Organic Chemistry, Nankai University, Tianjin 300071

出　　处：《Chinese Chemical Letters》2005年第10期1293-1296,共4页中国化学快报（英文版）

基　　金：The project supported by the National Natural Science Foundation of China(No.2017203 1);the Chinese Research Fund for the Doctoral Pr ogram of High Education.

摘　　要：A series of novel fluorine-containing acrylates 6a-6g were synthesized via the condensation of ethyl cyanoacetate and trifluoroacetic anhydride, followed by chloridization and the coupling reaction with amines. These new compounds exhibited some biological activity as preliminary bioassay indicated. A plausible reaction mechanism was outlined and discussed.A series of novel fluorine-containing acrylates 6a-6g were synthesized via the condensation of ethyl cyanoacetate and trifluoroacetic anhydride, followed by chloridization and the coupling reaction with amines. These new compounds exhibited some biological activity as preliminary bioassay indicated. A plausible reaction mechanism was outlined and discussed.

关 键 词：Fluorine-containing compound ACRYLATES synthesis. 

分 类 号：O623.624.3[理学—有机化学]