Synthesis and Anti-HIV Activity of Trisubstituted (3′R, 4′R)-3′,4′- Di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) Analogs  

作　　者：Chun Hong ZHAO Ting ZHOU Lan XIE Jing Yun LI Zuo Yi BAO Zhao Wen LOU Kuo Hsiung LEE 

机构地区：[1]Beijing Institute of Pharmacology ＆ Toxicology, Beijing 100850 [2]Department of Chemistry, Hubei University, Wuhan, Hubei 430062 [3]Beijing Institute of Microbiology ＆ Epidemiology,Beijing 100850 [4]School of Pharmacy, University of North Carolina at Chapel Hill,NC 27599, USA

出　　处：《Chinese Chemical Letters》2005年第10期1297-1300,共4页中国化学快报（英文版）

摘　　要：To further explore the potential of DCK analogs as anti-HIV drug candidates, ten new tri-substituted （3＇R,4＇R）-3＇,4＇-di-O-（S）-camphanoyl-（＋）-cis-khellactone （DCK） derivatives （4-13） were designed, synthesized, and evaluated against HIV replication in MT4 cells and H9 lympho- cytes.To further explore the potential of DCK analogs as anti-HIV drug candidates, ten new tri-substituted （3＇R,4＇R）-3＇,4＇-di-O-（S）-camphanoyl-（＋）-cis-khellactone （DCK） derivatives （4-13） were designed, synthesized, and evaluated against HIV replication in MT4 cells and H9 lympho- cytes.

关 键 词：anti-HIV agent DCK analogs synthesis. 

分 类 号：TQ463[化学工程—制药化工]