Synthesis of Novel Monophosphoramidite Ligands Derived from L-Proline for Rh-catalyzed Asymmetric Hydrogenation of α-Dehydroamino Acid Esters  

作　　者：Qing Heng ZENG Xiang Ping HU Xin Miao LIANG Zhuo ZHENG 

机构地区：[1]Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 [2]Graduate School of Chinese Academy of Sciences, Beijing 100039

出　　处：《Chinese Chemical Letters》2005年第10期1321-1323,共3页中国化学快报（英文版）

基　　金：The authors would like to thank the National Natural Science Foundation of China(20472083)for financial support.

摘　　要：Two novel monophosphoramidites were synthesized through a five-step transformation from commercially available L-proline. In the Rh-catalyzed asymmetric hydrogenation of α-dehydroamino acid derivatives, ligand （Sc,Rα）-1b showed good enantioselectivity and up to 91% e.e. was obtained.Two novel monophosphoramidites were synthesized through a five-step transformation from commercially available L-proline. In the Rh-catalyzed asymmetric hydrogenation of α-dehydroamino acid derivatives, ligand （Sc,Rα）-1b showed good enantioselectivity and up to 91% e.e. was obtained.

关 键 词：Monophosphoramidite L-PROLINE Rh-catalyzed asymmetric hydrogenation α-dehydroamino acid. 

分 类 号：O629.71[理学—有机化学]